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Table 1 Summary of genetic models simulated

From: A comparison of internal model validation methods for multifactor dimensionality reduction in the case of genetic heterogeneity

  First model Second model
Simulation Disease loci Model type Level of heterogeneity Odds ratio Contribution Odds ratio Contribution
1 2 additive 25/75 1.5 25% 1.5 75%
2 2 additive 25/75 2 25% 2 75%
3 2 additive 25/75 1.5 25% 2 75%
4 2 additive 25/75 2 25% 1.5 75%
5 2 additive 50/50 1.5 50% 1.5 50%
6 2 additive 50/50 2 50% 2 50%
7 2 additive 50/50 1.5 50% 2 50%
8 2 recessive 25/75 1.5 25% 1.5 75%
9 2 recessive 25/75 2 25% 2 75%
10 2 recessive 25/75 1.5 25% 2 75%
11 2 recessive 25/75 2 25% 1.5 75%
12 2 recessive 50/50 1.5 50% 1.5 50%
13 2 recessive 50/50 2 50% 2 50%
14 2 recessive 50/50 1.5 50% 2 50%
15 4 XOR 25/75 1.5 25% 1.5 75%
16 4 XOR 25/75 2 25% 2 75%
17 4 XOR 25/75 1.5 25% 2 75%
18 4 XOR 25/75 2 25% 1.5 75%
19 4 XOR 50/50 1.5 50% 1.5 50%
20 4 XOR 50/50 2 50% 2 50%
21 4 XOR 50/50 1.5 50% 2 50%