From expression pattern to genetic association in asthma and asthma-related phenotypes

BMC Research Notes

Table 3 Associated SNPs after correction with asthma-related phenotypes

Gene/ Corr. threshold^a	SNP	Allele MAF^b	Asthma			Atopy			Atopic asthma
Gene/ Corr. threshold^a	SNP	Allele MAF^b	Fam^c	Z	P value	Fam	Z	P value	Fam	Z	P value
*AGC1* /0.001	rs11630178	T/C 0.34	99	2.69	0.0070	82	3.59	0.0003	85	3.90	0.0001
*IFI6* /0.025	rs11247653	A/G 0.43	133	−2.35	0.0186	109	−1.77	0.0770	110	−1.90	0.0570
*ADRA2A* /0.025	rs11195299	G/A 0.06	56	−2.59	0.0097	54	−0.79	0.4283	53	−1.92	0.0527
*ADH1B* /0.003	rs13103321	G/T 0.48	135	−3.04	0.0024	114	−2.57	0.0103	114	−2.62	0.0088

^a Corrected threshold for multiple testing (considering independent tagSNPs and phenotypes).
^b Minor allele frequency observed in the sample.
^c Number of families that contributed to the test.
SNP= Single nucleotide polymorphism; MAF= Minor allele frequency; Fam= Families.

ISSN: 1756-0500