An Always Correlated gene expression landscape for ovine skeletal muscle, lessons learnt from comparison with an “equivalent” bovine landscape

Table 2 Identification of functional modules in the AC landscape

Module	Correlation cut-off						Description of the key GO term	GO enrichment P-value
	>0.95	>0.90	>0.85	>0.80	>0.70	none
Mitochondria	29¹	39	51 ²	40	35	35	mitochondrial electron transport, NADH to ubiquinone	2.0370*10^2E-26
Ribosome		18	37	23	29	33	translation	3.7793*10^3.8E-47
Muscle	6	10	12	10	10	10	muscle contraction, muscle system process	3.0278*10^3E-8
Regulation of ubiquitin-protein ligase activity			8	13	11	nd³	negative regulation of ubiquitin-protein ligase activity	1.2510*10^1.3E-5
Translation					6	nd	translational elongation	1.1387*10^1.1E-8

¹ Number of genes in each module for each correlation cut-off of the “AC” landscape was calculated using the MCODE plug-in in Cytoscape. A list of genes in each module is included in Additional file 3.
² Bold values have been taken as the optimal size of the module.
³ Module not detected.

ISSN: 1756-0500