Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer

BMC Research Notes

Table 3 Comparison of genotypic variations of the TYMS among individuals with BC and controls

	Genotypic variant of the TYMS
	2R/2R	2R/3R	3R/3R
SBC	04	22	05
Control	36	49	47
χ ²	2.80	10.4	3.53
p	0.11	0.001	0.06
OR	0.30	4.14	0.35
CI (95%)	(0.13-1.21)	(1.77-9.71)	(0.12-0.97)
HBC	03	25	09
Control	36	49	47
χ ²	5.94	9.68	1.9
p	0.01	0.002	0.27
OR	0.23	3.53	0.58
CI (95%)	(0.06-0.81)	(1.63-7.65)	(0.25-1.33)
BC	07	47	14
Control	36	49	47
χ ²	2.46	17.13	0.39
p	0.12	<0.001	0.53
OR	0.45	3.79	0.47
CI (95%)	(0.19-1.11)	(2.03-7.08)	(0.24-1.52)

χ² = Chi-square; OR = Odds Ratio; CI = Confidence Interval; In Bold = Significant Statistical Values; SBC = sporadic breast cancer; HBC = hereditary breast cancer; BC = breast cancer.

ISSN: 1756-0500