Phylogenetic tree of the WAVE proteins. The phylogenetic tree of the WAVE protein family was calculated from the multiple sequence alignment of the concatenated WHD and VCA domains using RAxML. For lack of space bootstrap support values are only given for major branches and indicated in percent. The WHD domains of a few NHS proteins have been used as outgroup. The unrooted tree was drawn with FigTree and branches were coloured according to class and taxonomic distributions. For the extended tree see Additional file 1.