Table 4 Predicted microRNAs targeting 5'-UTR, ORF and 3'-UTR region using miRWalk software
GABA receptor subunits | Entrez Gene symbol | MicroRNAs targeting 5'-UTR | MicroRNAs targeting ORF | Numbers of microRNA targeting 3'-UTR with p-value < 0.05 |
|---|---|---|---|---|
α1 | GABRA1 | miR-326, miR-28*, miR-29b-1*, | miR-341, miR-503, miR-150, miR-378 | 79 |
miR-539, miR-542-5p, miR-147, | ||||
miR-423, miR-598-5p | ||||
α2 | GABRA2 | N/A | N/A | N/A |
α3 | GABRA3 | miR-27b, miR-27a, miR-185, | miR-350, miR-431, miR-542-3p, miR-322, miR-323*, | 0 |
miR-343, miR-346, miR-17-5p, | miR-140, miR-148b-3p, miR-29a*, miR-152, miR-497 | |||
miR-93, miR-128, miR-143, | ||||
miR-291a-5p, miR-20b-5p | ||||
α4 | GABRA4 | N/A | N/A | N/A |
α5 | GABRA5 | miR-345, miR-22, miR-451, | miR-24-1*, miR-24-2*, let-7d, miR-346, miR-153, | 37 |
miR-541, miR-369 | miR-296, miR-376c, miR-466c | |||
α6 | GABRA6 | 0 | miR-126*, miR-743b, miR-323*, miR-330*, miR-21*, | 0 |
miR-153, miR-880 | ||||
β1 | GABRB1 | miR-323, miR-219-2 | miR-140, miR-351, miR-324-5p, miR-325-3p, miR-7a*, | 26 |
miR-10a-5p, miR-125a-5p, miR-125b-5p, miR-376b-5p, | ||||
miR-384-3p | ||||
β2 | GABRB2 | 0 | miR-20a*, miR-150, miR-297, miR-541 | 0 |
β3 | GABRB3 | miR-188 | miR-300-5p, miR-350, miR-433, miR-881, miR-672, | 17 |
γ1 | GABRG1 | miR-497, miR-322, miR-103-2, | miR-182, miR-216a, miR-483, miR-327, miR-338, | miR-126*, miR- |
miR-103-1, miR-107 | miR-205, miR-296, miR-320, miR-880 | 379, miR-742, | ||
miR-871 | ||||
γ2 | GABRG2 | 0 | miR-182, miR-483, miR-382, miR-505 | 0 |
γ3 | GABRG3 | miR-151*, miR-125a-3p | miR-142-3p, miR-298, miR-15b, miR-16, miR-28, | 14 |
miR-34a, miR-195, miR-214, miR-290, miR-449a, | ||||
miR-880, miR-708 | ||||
π | GABRP | miR-28, miR-708 | miR-345-5p, miR-199a-3p, miR-873 | 0 |
δ | GABRD | miR-210 | miR-322, miR-338, miR-193, miR-370, miR-497, miR-873 | 29 |
ε | GABRE | 0 | miR-485, miR-484, miR-342-3p, miR-344-5p, miR-223, | 0 |
miR-671, miR-322, miR-24, miR-139-3p, miR-199a-5p, | ||||
miR-298, miR-483, miR-497, miR-743b, miR-672 | ||||
θ | GABRQ | 0 | miR-350, miR-34c, miR-92a, miR-92a, miR-300-5p, | 0 |
miR-92b, miR-7a*, miR-32 | ||||
ρ1 | GABRR1 | miR-29b-1*, miR-26c | miR-338, let-7d, miR-204*, miR-421, miR-672, | 92 |
miR-674-3p | ||||
ρ2 | GABRR2 | miR-873, miR-134, miR-210, | miR-218*, let-7d, miR-34a, miR-204*, miR-421, | miR-191, |
miR-207, miR-380, | miR-449a, miR-431, miR-381, miR-674-3p | miR-872* | ||
ρ3 | GABRR3 | miR-350, miR-30c-1*, miR-30c- | miR-338, miR-341, miR-23a*, miR-143, miR-384-5p, | miR-191, miR- |
2*, miR-148b-3p, miR-152, | miR-324-3p, miR-30c, miR-30e, miR-30b-5p, miR-30d, | 344-1, miR-217, | ||
miR-872*, miR-874, miR-672 | miR-30a, miR-204*, miR-539, miR-742, miR-873 | miR-883, miR-484 |