Visual alignment of the linker region between NDM-1 and other B1 MBLs. NDM-1 is shown in red, against varying shades of gray for IMP-1, ccrA, VIM-2 and BlaB. N- and C-terminal regions align well across all B1 MBLs, but for NDM-1 the center of the linker region is distal, indicated by arrows and labeled by their positioning and residues within NDM-1. The shown structures correspond to 120-166 in ccrA, 98-143 in IMP-1, 138-200 in VIM-2, 138-200 in BcII and 141-193 in NDM-1; these ranges include N- and C-terminal anchor sequences that flank the linker region and are generally well conserved. Graphics were generated using PyMol .