Abnormal anxiety-like behaviors in Grin1Rgsc174/ Grin1+mice. (A) In the light/dark transition test, the number of transitions decreased in Grin1Rgsc174/Grin1+ mice compared to wild-type mice. No significant differences were detected in the time spent in the light compartment (B), latency to enter the light compartment (C), or distance traveled in the light/dark compartments (D). In the elevated plus maze test, the percentage of time spent in the open arms (E) and the percentage of entries into the open arms (F) were significantly increased in Grin1Rgsc174/Grin1+ mice. There were no significant differences between genotypes in the number of arm entries (G) or distance traveled (H). The p values indicate the genotype effect in one-way ANOVA.