Table 4 Adjusted risk ratios for factors independently associated with LTFU
From: Trends in mortality and loss to follow-up in HIV care at the Nkongsamba Regional hospital, Cameroon
Factor | Unadjusted Cox hazard ratios | P-values from LRT | Adjusted hazard ratios | P-values from LRT |
|---|---|---|---|---|
(95% Confidence intervals) | (95% Confidence intervals) | |||
Calendar year | ||||
2005 | 1.00 | 1.00 | ||
2006 | 0.53(0.29-0.97) | 0.48(0.26-0.87) | ||
2007 | 1.69(1.05-2.72) | 0.94(0.57-1.55) | <0.0001 | |
2008 | 1.21(0.75-1.96) | <0.0001 | 0.89(0.54-1.47) | |
2009 | 0.99(0.56-1.66) | 0.96(0.58-1.59) | ||
2010 | 0.60(0.34-1.06) | 0.45(0.25-0.78) | ||
Age group (years) | ||||
15 – 24 | 1.00 | 1.00 | ||
25 – 34 | 0.62(0.43-0.89) | 0.06 | 0.67(0.46-0.97) | |
35 – 44 | 0.67(0.47-0.97) | 0.71(0.49-1.04) | 0.21 | |
45+ | 0.60(0.41-0.88) | 0.66(0.44-0.98) | ||
Region | ||||
Littoral | 1.00 | 1.00 | ||
South-West | 1.29(0.67-2.50) | 0.02 | 1.32(0.33-5.32) | |
West | 0.36(0.16-0.81) | 1.69(0.36-7.83) | 0.03 | |
Other | 0.77(0.19-3.11) | 0.49(0.10-2.45) | ||
Marital status** | ||||
Single | 1.00 | 1.00 | ||
Monogamous | 0.65(0.50-0.84) | 0.66(0.51-0.85) | ||
Polygamous | 0.60(0.39-0.93) | 0.005 | 0.59(0.38-0.92) | 0.006 |
Divorced | 0.93(0.63-1.35) | 0.92(0.63-1.35) | ||
Widowed | 0.67(0.49-0.93) | 0.67(0.49-0.93) | ||
Partner HIV ** | ||||
Negative | 1.00 | 1.00 | ||
Positive-ART | 0.62(0.37-1.02) | 0.61(0.37-1.01) | ||
Positive + ART | 0.77(0.42-1.40) | 0.0003 | 0.72(0.40-1.30) | 0.0005 |
Unknown | 1.29(0.92-1.81) | 1.24(0.89-1.74) | ||
Distance(km)* | ||||
≤5 | 1.00 | 1.00 | ||
>5 | 1.22(0.98-1.51) | 0.07 | 1.25(1.00-1.55) | 0.01 |
NNRTI Regimen | ||||
EFV-based | 1.00 | 1.00 | 0.04 | |
NVP-based | 0.77(0.59-1.01) | 0.06 | 0.75(0.57-0.99) | |
NRTI Regimen | ||||
ABC/TDF-based | 0.13(0.02-0.93) | 0.19(0.03-1.39) | ||
AZT-based | 0.64(0.49-0.83) | <0.0001 | 0.59(0.45-0.77) | |
D4T-based | 0.55(0.43-0.71) | 0.55(0.42-0.71) | <0.0001 | |
None | 1.00 | 1.00 | ||
Immune deficiency | ||||
None | 1.00 | 1.00 | ||
Mild | 0.76(0.51-1.14) | <0.0001 | 0.75(0.50-1.13) | <0.0001 |
Advanced | 0.43(0.30-0.60) | 0.42(0.30-0.59) | ||
Severe | 0.55(0.41-0.75) | 0.54(0.40-0.74) | ||
Drug change | ||||
No | 1.00 | 1.00 | ||
Yes | 0.07(0.04-0.12) | <0.0001 | 0.07(0.04-0.12) | <0.0001 |
Cotrimoxazole | ||||
Prophylaxis | ||||
No | 1.00 | 0.004 | 1.00 | <0.0001 |
Yes | 0.45(0.30-0.75) | 0.47(0.30-0.74) |