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Table 4 Sensitivity and specificity of normalized MALAT1 and number of true-positive, true-negative, false-positive, and false-negative tests, calculated for different false positive rates (FPR), i.e., none, one, and two false-positive tests and maximum Youden’s Index (YI)

From: Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer

   Cutoff Sensitivity (%) Specificity (%) True-positive (N) True-negative (N) False-positive (N) False-negative (N)
NSCLC vs. controls FPR = 0% -0.24 47 100 21 25 0 24
  FPR = 4% -0.41 56 96 25 24 1 20
  FPR = 8% -0.42 56 92 25 23 2 20
  Maximum YI -0.41 56 96 25 24 1 20
AdCa vs. controls FPR = 0% -0.05 38 100 8 25 0 13
  FPR = 4% -0.35 48 96 10 24 1 11
  FPR = 8% -0.42 48 92 10 23 2 11
  Maximum YI -1.44 81 64 17 16 9 4
SqCC vs. controls FPR = 0% -0.24 54 100 13 25 0 11
  FPR = 4% -0.41 63 96 15 24 1 9
  FPR = 8% -0.42 63 92 15 23 2 9
  Maximum YI -0.41 63 96 15 24 1 9
AdCa vs. SqCC FPR = 0% 3.37 8 100 2 21 0 22
  FPR = 5% 2.76 8 95 2 20 1 22
  FPR = 10% 1.91 21 90 5 19 2 19
  Maximum YI 1.32 33 86 8 18 3 16