Table 4 Sensitivity and specificity of normalized MALAT1 and number of true-positive, true-negative, false-positive, and false-negative tests, calculated for different false positive rates (FPR), i.e., none, one, and two false-positive tests and maximum Youden’s Index (YI)
Cutoff | Sensitivity (%) | Specificity (%) | True-positive (N) | True-negative (N) | False-positive (N) | False-negative (N) | ||
|---|---|---|---|---|---|---|---|---|
NSCLC vs. controls | FPR = 0% | -0.24 | 47 | 100 | 21 | 25 | 0 | 24 |
FPR = 4% | -0.41 | 56 | 96 | 25 | 24 | 1 | 20 | |
FPR = 8% | -0.42 | 56 | 92 | 25 | 23 | 2 | 20 | |
Maximum YI | -0.41 | 56 | 96 | 25 | 24 | 1 | 20 | |
AdCa vs. controls | FPR = 0% | -0.05 | 38 | 100 | 8 | 25 | 0 | 13 |
FPR = 4% | -0.35 | 48 | 96 | 10 | 24 | 1 | 11 | |
FPR = 8% | -0.42 | 48 | 92 | 10 | 23 | 2 | 11 | |
Maximum YI | -1.44 | 81 | 64 | 17 | 16 | 9 | 4 | |
SqCC vs. controls | FPR = 0% | -0.24 | 54 | 100 | 13 | 25 | 0 | 11 |
FPR = 4% | -0.41 | 63 | 96 | 15 | 24 | 1 | 9 | |
FPR = 8% | -0.42 | 63 | 92 | 15 | 23 | 2 | 9 | |
Maximum YI | -0.41 | 63 | 96 | 15 | 24 | 1 | 9 | |
AdCa vs. SqCC | FPR = 0% | 3.37 | 8 | 100 | 2 | 21 | 0 | 22 |
FPR = 5% | 2.76 | 8 | 95 | 2 | 20 | 1 | 22 | |
FPR = 10% | 1.91 | 21 | 90 | 5 | 19 | 2 | 19 | |
Maximum YI | 1.32 | 33 | 86 | 8 | 18 | 3 | 16 |