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Table 2 Serum concentrations of 25 cytokines and chemokines (pg/ml) between 3 study groups during first week of life

From: Levels of 25 cytokines in the first seven days of life in newborn infants

Cytokinec/chemokines GROUP
After birth hours ≤ 32 wks (n = 11) 33 - 35 wks (n = 14) ≥ 36 wks (n = 9)
1. IL1B:        
  - 0 0 (0–15) 1 (0–23) 7 (0–17)
  - 4 0 (0–4) 1 (0–30) 4 (0–20)
  - 24-72 0 (0–1) 1 (0,25-7,75) 4 (0,5-23)
  - 96-168    4 (0,75-17) 4 (0–14)
2. IL1RA:        
  - 0 413 (158–931) 512 (179–22246) 803 (200–2376)
  - 4 2026 (63–13795) 596 (119–10464) 4183 (331–14702)
  - 24-72 242 (168–354)@& 508,5 (737,3-302,5) 545 (407–698)
  - 96-168    395,5 (309,8-556,8) 441 (179–613)
3. IL2:        
  - 0 3,5 (3–7) 4 (1–15) 14 (3–18)
  - 4 3 (3–5)@ 4 (1–17) 14 (4–17)
  - 24-72 3.5 (3–6.75)@ 4 (3–10,5) 14 (5–15,5)
  - 96-168    9,5 (3–16,5) 14 (13–16)
4. IL2R:        
  - 0 325 (236–427) 365 (202–604) 295 (145–507)
  - 4 300,5 (219–443) 349 (179–621) 295 (212–604)
  - 24-72 458 (332–617) 427 (268,5-556) 507 (387,5-631,5)
  - 96-168    692 (356,5-846) 610 (572–652)
5. IL4:        
  - 0 2 (0–5) 5 (2–112) 2 (1–3)
  - 4 2 (0–5) 5 (2–128) 5 (1–10)
  - 24-72 2 (0–2) 4 (2–94) 3 (1–5,5)
  - 96-168    4,5 (2–22) 3 (1–6)
6. IL5:        
  - 0 2 (0–2) 5 (0–34) 6 (0–8)
  - 4 2 (0–3) 5 (0–33) 6 (0–8)
  - 24-72 2,5 (2–4) 5 (2–7) 6 (2,3-8)
  - 96-168    8,5 (6–9,5) 6 (6–7)
7. IL6:        
  - 0 15 (0–1440) 30,5 (1–418) 79 (64–232)
  - 4 12 (1–251) 26 (1–212) 94 (7–3135)
  - 24-72 4 (1,75-11)@ 5,5 (2–16)@ 17 (3–38)
  - 96-168    9,5 (5–29) 3 (2–8,8)
8. IL7:        
  - 0 0 (0–0) 6 (0–40) 0,5 (0–1)
  - 4 0 (0–12) 3 (0–32) 0,5 (0–3)
  - 24-72 0 (0–0) 0 (0–8) 0 (0–6)
  - 96-168    3,5 (0–13,5) 0 (0–5,5)
9. IL8:        
  - 0 57 (8–204) 98,5 (1–396) 40 (34–46)
  - 4 28,5 (10–157) 46 (1–189) 82,5 (13–189)
  - 24-72 19,5 (12,7-39,7)@& 44 (22,75-85,5) 57 (28–170)
  - 96-168    44,5 (24–78,25) 37,5 (13–64,3)
10. IL10:        
  - 0 3 (3–29) 14,5 (0–74) 22 (22–25)
  - 4 3,5 (1–28) 9 (1–49) 23 (2–48)
  - 24-72 3 (2–3)@ 3 (2–11)@ 21 (3,3-22)
  - 96-168    14 (3–21) 21 (3–21,8)
11. IL12:        
  - 0 418,5 (179–693) 473 (215–815) 278 (202–1837)
  - 4 461,5 (144–628) 345 (171–960) 1151 (258–1883)
  - 24-72 263 (225–339)@& 384 (199,8-517,8) 402 (295,5-499,3)
  - 96-168    358 (243,8-445,8) 431 (219–602)
12. IL13:        
  - 0 0 (0–7) 7 (0–26) 12 (0–70)
  - 4 0 (0–7) 1 (0–22) 14,5 (0–81)
  - 24-72 0 (0–7)@ 1,5 (0–8,5) 12 (0–25)
  - 96-168    7 (0–17) 17 (12–26)
13. IL15:        
  - 0 0 (0–0) 13 (0–64) 37 (0–49)
  - 4 0 (0–0)@& 10 (0–49) 39 (0–53)
  - 24-72 0 (0–0)@& 13 (0–42) 41 (0–53)
  - 96-168    39,5 (0–52) 37 (28–47)
14. IL17:        
  - 0 0 (0–0) 36 (0–130) 23 (0–33)
  - 4 0 (0–6)@& 26 (0–146) 22 (6–38)
  - 24-72 0 (0–1)@& 27,5 (0,8-44,8) 18 (8,5-31,5)
  - 96-168    29 (4,5-41,8) 19 (0–28)
15. TNFA:        
  - 0 0 (0–0) 1 (0–6) 3 (0–6)
  - 4 0 (0–0)@& 1 (0–7) 3 (0–5)
  - 24-72 0 (0–0)@& 1 (0–3,8) 3 (0–4,5)
  - 96-168    4 (0–6,3) 4 (0–4)
16. IFNA:        
  - 0 36 (20–49) 40 (18–88) 30 (8–58)
  - 4 20 (0–49) 36 (18–98) 49 (20–79)
  - 24-72 36 (22,5-49) 49 (26–64,5) 36 (30–44,5)
  - 96-168    44,5 (36–75) 40 (30–49)
17. IFNG:        
  - 0 3 (3–3) 8 (2–449) 7 (3–8)
  - 4 3 (2–4) 8 (3–603) 7 (3–9)
  - 24-72 3 (3–3,75)@& 7,5 (3–43) 7 (4–8,5)
  - 96-168    8 (4–15,5) 7 (7–8)
18. GM_CSF:        
  - 0 0 (0–0) 1 (0–48) 0 (0–1)
  - 4 0 (0–0) 1 (0–27) 0 (0–34)
  - 24-72 0 (0–0) 0 (0–2) 0 (0–10,5)
  - 96-168    1 (0–22) 0 (0–7)
19. MIP1A:        
  - 0 24 (22–32) 28 (23–150) 28 (19–34)
  - 4 23 (22–34) 26 (18–150) 30 (23–36)
  - 24-72 23,5 (23–25)@& 29,5 (25–36,8) 28 (26–37)
  - 96-168    30 (25–38,8) 26 (24–32)
20. MIP1B:        
  - 0 82 (23–191) 74 (34–345) 40 (22–237)
  - 4 74 (51–133) 66 (41–550) 83 (57–250)
  - 24-72 41,5 (21–110,75) 80 (54–145,5) 66 (47,3-120,3)
  - 96-168    86,5 (45,5-149,3) 60 (42–90)
21. IP10:        
  - 0 19 (8–144) 32,5 (8–85) 115 (16–124)
  - 4 29,5 (3–162) 29 (6–119) 72,5 (19–119)
  - 24-72 24,5 (16–54)@ 37 (18,8-56,3) 82,5 (47–136,8)
  - 96-168    61 (39–140,3) 55,5 (34–133,75)
22. MIG:        
  - 0 32 (23–71)@ 41 (8–118) 0 (0–8)
  - 4 23 (0–41) 23 (0–145) 8 (0–47)
  - 24-72 23 (23–41) 35,5 (23–57) 41 (2–47)
  - 96-168    61 (39–140,3) 23 (8–47)
23. EOTAXIN:        
  - 0 24 (14–37) 35 (10–221) 9 (4–40)
  - 4 30,5 (11–80) 33 (10–86) 39 (12–220)
  - 24-72 30 (16,5-65) 51 (36,5-81,5) 32,5 (26,3-61,5)
  - 96-168    54 (28,5-67,5) 41 (25–55)
24. RANTES:        
  - 0 1200 (1200–4967) 1200 (1000–18288) 1000 (1000–1200)
  - 4 1200 (1200–9900) 1200 (1000–18248) 1000 (1000–1443)
  - 24-72 1200 (1200–2821) 1200 (1200–10608,8) 1000 (1000–1200)
  - 96-168    1100 (1000–1718,8) 1000 (1000–1132)
25. MCP1:        
  - 0 439,5 (234–3238) 399 (120–2252) 163 (69–2786)
  - 4 355,5 (0–3841) 433 (84–1685) 1119 (210–11314)
  - 24-72 275,5 (141–516)@ 463 (319,8-836) 934 (401–3650)
  - 96-168    378 (270,8-650,3) 406 (189–879)
  1. Data shown as median (min-max).
  2. Used Mann Whitney U test.
  3. @: p < 0.01; comparison between group ≤32 wks / 33–35 wks and group term.
  4. &: p < 0.01; comparison betweeen group ≤32 wks and group 33–35 wks.
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