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Table 2 Serum concentrations of 25 cytokines and chemokines (pg/ml) between 3 study groups during first week of life

From: Levels of 25 cytokines in the first seven days of life in newborn infants

Cytokinec/chemokines

GROUP

After birth hours

≤ 32 wks (n = 11)

33 - 35 wks (n = 14)

≥ 36 wks (n = 9)

1.

IL1B:

       
 

-

0

0

(0–15)

1

(0–23)

7

(0–17)

 

-

4

0

(0–4)

1

(0–30)

4

(0–20)

 

-

24-72

0

(0–1)

1

(0,25-7,75)

4

(0,5-23)

 

-

96-168

  

4

(0,75-17)

4

(0–14)

2.

IL1RA:

       
 

-

0

413

(158–931)

512

(179–22246)

803

(200–2376)

 

-

4

2026

(63–13795)

596

(119–10464)

4183

(331–14702)

 

-

24-72

242

(168–354)@&

508,5

(737,3-302,5)

545

(407–698)

 

-

96-168

  

395,5

(309,8-556,8)

441

(179–613)

3.

IL2:

       
 

-

0

3,5

(3–7)

4

(1–15)

14

(3–18)

 

-

4

3

(3–5)@

4

(1–17)

14

(4–17)

 

-

24-72

3.5

(3–6.75)@

4

(3–10,5)

14

(5–15,5)

 

-

96-168

  

9,5

(3–16,5)

14

(13–16)

4.

IL2R:

       
 

-

0

325

(236–427)

365

(202–604)

295

(145–507)

 

-

4

300,5

(219–443)

349

(179–621)

295

(212–604)

 

-

24-72

458

(332–617)

427

(268,5-556)

507

(387,5-631,5)

 

-

96-168

  

692

(356,5-846)

610

(572–652)

5.

IL4:

       
 

-

0

2

(0–5)

5

(2–112)

2

(1–3)

 

-

4

2

(0–5)

5

(2–128)

5

(1–10)

 

-

24-72

2

(0–2)

4

(2–94)

3

(1–5,5)

 

-

96-168

  

4,5

(2–22)

3

(1–6)

6.

IL5:

       
 

-

0

2

(0–2)

5

(0–34)

6

(0–8)

 

-

4

2

(0–3)

5

(0–33)

6

(0–8)

 

-

24-72

2,5

(2–4)

5

(2–7)

6

(2,3-8)

 

-

96-168

  

8,5

(6–9,5)

6

(6–7)

7.

IL6:

       
 

-

0

15

(0–1440)

30,5

(1–418)

79

(64–232)

 

-

4

12

(1–251)

26

(1–212)

94

(7–3135)

 

-

24-72

4

(1,75-11)@

5,5

(2–16)@

17

(3–38)

 

-

96-168

  

9,5

(5–29)

3

(2–8,8)

8.

IL7:

       
 

-

0

0

(0–0)

6

(0–40)

0,5

(0–1)

 

-

4

0

(0–12)

3

(0–32)

0,5

(0–3)

 

-

24-72

0

(0–0)

0

(0–8)

0

(0–6)

 

-

96-168

  

3,5

(0–13,5)

0

(0–5,5)

9.

IL8:

       
 

-

0

57

(8–204)

98,5

(1–396)

40

(34–46)

 

-

4

28,5

(10–157)

46

(1–189)

82,5

(13–189)

 

-

24-72

19,5

(12,7-39,7)@&

44

(22,75-85,5)

57

(28–170)

 

-

96-168

  

44,5

(24–78,25)

37,5

(13–64,3)

10.

IL10:

       
 

-

0

3

(3–29)

14,5

(0–74)

22

(22–25)

 

-

4

3,5

(1–28)

9

(1–49)

23

(2–48)

 

-

24-72

3

(2–3)@

3

(2–11)@

21

(3,3-22)

 

-

96-168

  

14

(3–21)

21

(3–21,8)

11.

IL12:

       
 

-

0

418,5

(179–693)

473

(215–815)

278

(202–1837)

 

-

4

461,5

(144–628)

345

(171–960)

1151

(258–1883)

 

-

24-72

263

(225–339)@&

384

(199,8-517,8)

402

(295,5-499,3)

 

-

96-168

  

358

(243,8-445,8)

431

(219–602)

12.

IL13:

       
 

-

0

0

(0–7)

7

(0–26)

12

(0–70)

 

-

4

0

(0–7)

1

(0–22)

14,5

(0–81)

 

-

24-72

0

(0–7)@

1,5

(0–8,5)

12

(0–25)

 

-

96-168

  

7

(0–17)

17

(12–26)

13.

IL15:

       
 

-

0

0

(0–0)

13

(0–64)

37

(0–49)

 

-

4

0

(0–0)@&

10

(0–49)

39

(0–53)

 

-

24-72

0

(0–0)@&

13

(0–42)

41

(0–53)

 

-

96-168

  

39,5

(0–52)

37

(28–47)

14.

IL17:

       
 

-

0

0

(0–0)

36

(0–130)

23

(0–33)

 

-

4

0

(0–6)@&

26

(0–146)

22

(6–38)

 

-

24-72

0

(0–1)@&

27,5

(0,8-44,8)

18

(8,5-31,5)

 

-

96-168

  

29

(4,5-41,8)

19

(0–28)

15.

TNFA:

       
 

-

0

0

(0–0)

1

(0–6)

3

(0–6)

 

-

4

0

(0–0)@&

1

(0–7)

3

(0–5)

 

-

24-72

0

(0–0)@&

1

(0–3,8)

3

(0–4,5)

 

-

96-168

  

4

(0–6,3)

4

(0–4)

16.

IFNA:

       
 

-

0

36

(20–49)

40

(18–88)

30

(8–58)

 

-

4

20

(0–49)

36

(18–98)

49

(20–79)

 

-

24-72

36

(22,5-49)

49

(26–64,5)

36

(30–44,5)

 

-

96-168

  

44,5

(36–75)

40

(30–49)

17.

IFNG:

       
 

-

0

3

(3–3)

8

(2–449)

7

(3–8)

 

-

4

3

(2–4)

8

(3–603)

7

(3–9)

 

-

24-72

3

(3–3,75)@&

7,5

(3–43)

7

(4–8,5)

 

-

96-168

  

8

(4–15,5)

7

(7–8)

18.

GM_CSF:

       
 

-

0

0

(0–0)

1

(0–48)

0

(0–1)

 

-

4

0

(0–0)

1

(0–27)

0

(0–34)

 

-

24-72

0

(0–0)

0

(0–2)

0

(0–10,5)

 

-

96-168

  

1

(0–22)

0

(0–7)

19.

MIP1A:

       
 

-

0

24

(22–32)

28

(23–150)

28

(19–34)

 

-

4

23

(22–34)

26

(18–150)

30

(23–36)

 

-

24-72

23,5

(23–25)@&

29,5

(25–36,8)

28

(26–37)

 

-

96-168

  

30

(25–38,8)

26

(24–32)

20.

MIP1B:

       
 

-

0

82

(23–191)

74

(34–345)

40

(22–237)

 

-

4

74

(51–133)

66

(41–550)

83

(57–250)

 

-

24-72

41,5

(21–110,75)

80

(54–145,5)

66

(47,3-120,3)

 

-

96-168

  

86,5

(45,5-149,3)

60

(42–90)

21.

IP10:

       
 

-

0

19

(8–144)

32,5

(8–85)

115

(16–124)

 

-

4

29,5

(3–162)

29

(6–119)

72,5

(19–119)

 

-

24-72

24,5

(16–54)@

37

(18,8-56,3)

82,5

(47–136,8)

 

-

96-168

  

61

(39–140,3)

55,5

(34–133,75)

22.

MIG:

       
 

-

0

32

(23–71)@

41

(8–118)

0

(0–8)

 

-

4

23

(0–41)

23

(0–145)

8

(0–47)

 

-

24-72

23

(23–41)

35,5

(23–57)

41

(2–47)

 

-

96-168

  

61

(39–140,3)

23

(8–47)

23.

EOTAXIN:

       
 

-

0

24

(14–37)

35

(10–221)

9

(4–40)

 

-

4

30,5

(11–80)

33

(10–86)

39

(12–220)

 

-

24-72

30

(16,5-65)

51

(36,5-81,5)

32,5

(26,3-61,5)

 

-

96-168

  

54

(28,5-67,5)

41

(25–55)

24.

RANTES:

       
 

-

0

1200

(1200–4967)

1200

(1000–18288)

1000

(1000–1200)

 

-

4

1200

(1200–9900)

1200

(1000–18248)

1000

(1000–1443)

 

-

24-72

1200

(1200–2821)

1200

(1200–10608,8)

1000

(1000–1200)

 

-

96-168

  

1100

(1000–1718,8)

1000

(1000–1132)

25.

MCP1:

       
 

-

0

439,5

(234–3238)

399

(120–2252)

163

(69–2786)

 

-

4

355,5

(0–3841)

433

(84–1685)

1119

(210–11314)

 

-

24-72

275,5

(141–516)@

463

(319,8-836)

934

(401–3650)

 

-

96-168

  

378

(270,8-650,3)

406

(189–879)

  1. Data shown as median (min-max).
  2. Used Mann Whitney U test.
  3. @: p < 0.01; comparison between group ≤32 wks / 33–35 wks and group term.
  4. &: p < 0.01; comparison betweeen group ≤32 wks and group 33–35 wks.
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BMC Research Notes

ISSN: 1756-0500

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