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Table 3 Univariate and multivariate analyses for demographic, clinical and genetic data with overall survival for colorectal cancer patients treated with FOLFIRI® and bevacizumab (n = 45)

From: FOLFIRI® and Bevacizumab in first-line treatment for colorectal cancer patients: safety, efficacy and genetic polymorphisms

  Univariate Multivariate
  N(45) HR [95% CI] P HR [95% CI] P(Wald)
Sex: Male 16 (35.6) ref.   ref. ref.
Female 29 (64.4) 0.43 [0.20; 0.90] 0.02 0.38 [0.18; 0.82] 0.01
Age, y: <=65 20 (44.4) ref.    
> 65 25 (55.6) 1.09 [0.52; 2.28] 0.81 - -
ECOG/PS: 0 16 (35.6) ref.    
1-2 29 (64.4) 1.26 [0.60; 2.70] 0.55 - -
Primary tumor: Colon 28 (62.2) ref.    
Rectum 17 (37.8) 1.16 [0.56; 2.40] 0.69 - -
Non-mucinous: No 5 (11.1) ref.    
Yes 40 (88.9) 0.45 [0.15; 1.36] 0.15 - -
Metastatic sites: 1 13 (28.9) ref.    
>1 32 (71.1) 0.77 [0.36; 1.65] 0.50 - -
Liver-only metas.: No 33 (73.3) ref.    
Yes 12 (26.7) 1.14 [0.52; 2.52] 0.74 - -
Resected primary tumor: No 10 (22.2) ref.    
Yes 35 (77.8) 0.67 [0.29; 1.51] 0.33 - -
Previous adjuvant CT*: No 34 (75.6) ref.    
Yes 11 (24.4) 0.85 [0.36; 1.98] 0.70 - -
High ALP: No 23 (51.1) ref.   ref. ref.
Yes 19 (42.2) 2.80 [1.25; 6.26] <0.009 4.21 [1.44; 12.31] 0.008
High LDH§: No 16 (35.6) ref.    
Yes 13 (28.9) 4.73 [1.42; 15.81] <0.006 1.46 [0.62; 3.43] 0.39
High ACE††: No 17 (37.8) ref.    
Yes 22 (48.9) 2.07 [0.91; 4.72] 0.08 - -
rs25648: C 34 (75.6) ref.   ref. ref.
H/V 11 (24.4) 3.605 [1.57;8.30] 0.01** 3.58 [1.50; 8.57] 0.004
rs2010963: C 17 (37.8) ref.    
H/V 28 (62.2) 1.228 [0.59;2.56] 0.58 - -
rs699947: C 34 (75.6) ref.    
H/V 11 (24.4) 1.324 [0.59;2.99] 0.50 - -
rs8175347: C 15 (33.3) ref.    
H/V 30 (66.7) 0.632 [0.30;1.35] 0.23 - -
3′UTR: C 23 (51.1) ref.    
H/V 22 (48.9) 1.298 [0.64;2.63] 0.47 - -
5′UTR: V 11 (24.4) ref.    
C/H 33 (73.3) 0.972 [0.44;2.13] 0.94 - -
5′UTR: C 13 (28.9) ref.    
H/V 31 (68.9) 0.886 [0.41;1.91] 0.76 - -
  1. *CT = chemotherapy.
  2. **P-value corrected to false discovery rate of 5% [19].
  3. ALP = alkaline phosphatase, Missing: 3 (6.7).
  4. §LDH = lactate Dehydrogenase, Missing: 16 (35.6).
  5. ††ACE = angiotensin-converting Enzyme, Missing: 6 (13.3).