Univariate | Multivariate | ||||
---|---|---|---|---|---|
N(45) | HR [95% CI] | P | HR [95% CI] | P(Wald) | |
Sex: Male | 16 (35.6) | ref. | ref. | ref. | |
Female | 29 (64.4) | 0.43 [0.20; 0.90] | 0.02 | 0.38 [0.18; 0.82] | 0.01 |
Age, y: <=65 | 20 (44.4) | ref. | |||
> 65 | 25 (55.6) | 1.09 [0.52; 2.28] | 0.81 | - | - |
ECOG/PS: 0 | 16 (35.6) | ref. | |||
1-2 | 29 (64.4) | 1.26 [0.60; 2.70] | 0.55 | - | - |
Primary tumor: Colon | 28 (62.2) | ref. | |||
Rectum | 17 (37.8) | 1.16 [0.56; 2.40] | 0.69 | - | - |
Non-mucinous: No | 5 (11.1) | ref. | |||
Yes | 40 (88.9) | 0.45 [0.15; 1.36] | 0.15 | - | - |
Metastatic sites: 1 | 13 (28.9) | ref. | |||
>1 | 32 (71.1) | 0.77 [0.36; 1.65] | 0.50 | - | - |
Liver-only metas.: No | 33 (73.3) | ref. | |||
Yes | 12 (26.7) | 1.14 [0.52; 2.52] | 0.74 | - | - |
Resected primary tumor: No | 10 (22.2) | ref. | |||
Yes | 35 (77.8) | 0.67 [0.29; 1.51] | 0.33 | - | - |
Previous adjuvant CT*: No | 34 (75.6) | ref. | |||
Yes | 11 (24.4) | 0.85 [0.36; 1.98] | 0.70 | - | - |
High ALP†: No | 23 (51.1) | ref. | ref. | ref. | |
Yes | 19 (42.2) | 2.80 [1.25; 6.26] | <0.009 | 4.21 [1.44; 12.31] | 0.008 |
High LDH§: No | 16 (35.6) | ref. | |||
Yes | 13 (28.9) | 4.73 [1.42; 15.81] | <0.006 | 1.46 [0.62; 3.43] | 0.39 |
High ACE††: No | 17 (37.8) | ref. | |||
Yes | 22 (48.9) | 2.07 [0.91; 4.72] | 0.08 | - | - |
rs25648: C | 34 (75.6) | ref. | ref. | ref. | |
H/V | 11 (24.4) | 3.605 [1.57;8.30] | 0.01** | 3.58 [1.50; 8.57] | 0.004 |
rs2010963: C | 17 (37.8) | ref. | |||
H/V | 28 (62.2) | 1.228 [0.59;2.56] | 0.58 | - | - |
rs699947: C | 34 (75.6) | ref. | |||
H/V | 11 (24.4) | 1.324 [0.59;2.99] | 0.50 | - | - |
rs8175347: C | 15 (33.3) | ref. | |||
H/V | 30 (66.7) | 0.632 [0.30;1.35] | 0.23 | - | - |
3′UTR: C | 23 (51.1) | ref. | |||
H/V | 22 (48.9) | 1.298 [0.64;2.63] | 0.47 | - | - |
5′UTR: V | 11 (24.4) | ref. | |||
C/H | 33 (73.3) | 0.972 [0.44;2.13] | 0.94 | - | - |
5′UTR: C | 13 (28.9) | ref. | |||
H/V | 31 (68.9) | 0.886 [0.41;1.91] | 0.76 | - | - |