New reliable scoring system, Toyama mouse score, to evaluate locomotor function following spinal cord injury in mice

Table 3 TMS point table for the open field locomotor performance of SCI mice

Ankle movement				Movement in other joints³⁾		Toe movement⁴⁾		Touchable area of the sole				Coordination⁵⁾		Hindlimb movement at stepping		Body supporting
Frequency¹⁾		Mobile extent²⁾		Movement in other joints³⁾		Toe movement⁴⁾		At resting		At stepping		Coordination⁵⁾		Hindlimb movement at stepping		Body supporting
No (0)	0	No (0)	0	No	0	No	0	No	0	No	0	No	0	No	0	No	0
<50%	1	<50%	1	Yes	1	Yes	1	Partial sole touch	1	Partial sole touch	1	Yes	1	Rotative	1	Sometimes support of hind body trunk	5
≥50%	2	≥50%	2					Full sole touch	2	Full sole touch, frequency <50%	2			Parallel	2	Always support of the body trunk, but unstable weight support	10
										Full sole touch, frequency ≥ 50%	3					Always support of the body trunk, and stable weight support	15
										Full sole tohch in every steps	4

Definitions
¹⁾Frequency: a ratio of the number of stepping forward with the ankle movement in all steppings.
²⁾Mobile extent: Mobile extent observed in a normal mouse is defined as 100%.
³⁾Movement of the knee joint or hip joint.
⁴⁾Toe movement: Toes movement, but not spasm.
⁵⁾Coordination: Correspondence between the forelimbs and hindlimbs in steppings.

ISSN: 1756-0500