Table 1 Summary of published reports on meningitis and brain abscesses caused by Fusobacterium nucleatum
Age/sex | Surgical treatment | Antibiotic therapy | Neurological symptoms | Detection of F. nucleatum | Therapeutic outcome | |
|---|---|---|---|---|---|---|
Stefániková L et al. 2008 [18] | 41/M | NO | cefotaxime, metronidazole, subsequently co-trimoxazole and rifampin | headache, fever, slightly hemiparesis of the right leg | PCR | survived, total recovery |
Kai A et al. 2008 [12] | 47/M | NO | ceftriaxone, metronidazole | headache, neck pain, fever, vomiting, transient loss of consciousness | culture | survived, total recovery |
Taguchi Y et al. 1981 [14] | 28/M | YES | penicillin G, chloramphenicol | pain left temporal region, general convulsion | culture | survived, total recovery |
Heckmann JG et al. 2003 [10] | 59/F | NO | ceftriaxone, metronidazole | confusion, neck stiffness, history of moderate ethanol | PCR | survived, total recovery |
Keller PM et al. 2010 [13] | 29/M | YES | ceftriaxone, metronidazole | seizure, frontal headache | PCR | survived, residual chronic headache |
Hsieh MJ et al. 2007 [11] | 71/F | YES | penicillin G, chloramphenicol | headache, fever, seizure, visual disturbance, hemiparesis | culture | survived, hemiparesis |
58/M | YES | penicillin G, metronidazole | headache, fever, visual disturbance, stiff neck | culture | survived, hemiparesis, homonymous hemianopia | |
64/M | YES | penicillin G, chloramphenicol | fever, seizure | culture | survived, total recovery | |
34/M | YES | ceftriaxone, metronidazole | headache, fever, vomiting, stiff neck | culture | survived, total recovery | |
52/M | YES | ceftriaxone, metronidazole | hemiparesis | culture | survived, wheelchair-bound | |
51/M | YES | ceftriaxone, vancomycin, metronidazole | fever, consciousness disturbance | culture | survived, total recovery | |
Han XY et al. 2003 [9] | 45/M | YES | penicillin G, metronidazole, ceftazidime | headache, short term memory loss, slurred speach | culture | survived |
56/M | YES | vancomycin, ceftazidime, metronidazole | headache, confusion, disorientation, left visual field deficits | culture | survived | |
74/M | YES | vancomycin, metronidazole, cefepime | garbled speech, incomplete paresis of the right hand | culture | survived | |
48/M | YES | ceftriaxone, metronidazole | headache, speech difficulty, confusion, memory loss | culture | survived | |
59/M | YES | vancomycin, ceftazidime, metronidazole | memory loss, right-side weakness, aphasia | culture | survived |