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Table 1 Association between SNPs and DAD in DS

From: Genetic variants conferring susceptibility to Alzheimer’s disease in the general population; do they also predispose to dementia in Down’s syndrome

Nearest gene SNP Risk allele Hazard ratio SE p-value
CR1 rs3818361 A 1.10 0.17 0.59
BIN1 rs744373 G 1.16 0.16 0.36
CD2AP rs9349407 C 0.99 0.15 0.93
EPHA1 rs11767557 T 1.03 0.16 0.86
CLU rs1532278 C 1.05 0.13 0.69
MS4A6A rs610932 G 1.03 0.15 0.83
PICALM rs561655 A 0.67 0.14 5.89 × 10-3
ABCA7 rs3764650 G 1.09 0.29 0.76
CD33 rs3865444 C 0.83 0.15 0.22
Genetic risk score - 0.97 0.06 0.66
  1. Covariates included in the analyses were sex, intellectual disability and APOE genotype.