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Table 2 Association between genetic variants and mortality

From: Genetic variants conferring susceptibility to Alzheimer’s disease in the general population; do they also predispose to dementia in Down’s syndrome

   Risk allele All subjects (N = 233)* Subjects with Dementia (N = 109)** Subjects without dementia (N = 124)**
Nearest gene SNP A Hazard ratio SE p -value Hazard ratio SE p -value Hazard ratio SE p -value
CR1 rs3818361 G 1.65 0.18 5.36 × 10-3 2.33 0.29 4.08 × 10-3 1.35 0.23 0.19
BIN1 rs744373 C 1.05 0.20 0.82 1.34 0.44 0.51 0.94 0.25 0.81
CD2AP rs9349407 T 1.10 0.18 0.61 1.92 0.31 0.04 0.82 0.23 0.40
EPHA1 rs11767557 C 1.23 0.19 0.29 0.76 0.35 0.44 1.47 0.24 0.10
CLU rs1532278 G 1.17 0.16 0.33 0.89 0.32 0.73 1.27 0.20 0.23
MS4A6A rs610932 A 0.72 0.18 0.07 1.02 0.34 0.95 0.64 0.21 0.03
PICALM rs561655 G 0.71 0.17 0.05 0.94 0.36 0.86 0.64 0.21 0.04
ABCA7 rs3764650 C 1.08 0.33 0.81 1.27 0.54 0.65 0.74 0.46 0.52
CD33 rs3865444 0.73 0.18 0.08 0.53 0.33 0.05 0.91 0.21 0.67
Genetic risk score -   1.70 0.25 0.03 3.13 0.52 0.03 1.54 0.28 0.13
  1. *Covariates included in the analyses were sex, intellectual disability and dementia; **Covariates included in the analyses were sex and intellectual disability.