Sequence analysis of BIG3. The locations of the two domains identified by Pfam and SMART are shown at the top. Shown below are the results of secondary structure and disorder predictions: red, α-helical; grey, coil; and green, disorder. The three segments underneath, A, B and C, indicate the query sequences for the BLAST, FUGUE and HHpred searches. The FUGUE hits are shown below and the BLAST results are summarized in the table at the bottom.