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Figure 2 | BMC Research Notes

Figure 2

From: HMM-ModE: implementation, benchmarking and validation with HMMER3

Figure 2

Comparison of number of false positives while using HMMER and HMM-ModE. The line diagram in this figure shows a comparison of number of false positives picked up by each of the GPCR subfamily profiles using HMMER profiles with default threshold and the HMM-ModE profiles with a discriminating threshold (similar to the GA1 threshold used by Pfam) generated through 10-fold cross validation as discussed in our published work [9]. As shown in the figure, there is a remarkable reduction in the number of false positives when our method is used which is helpful in the annotation of protein sequences with high specificity.

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