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Table 1 Expression of HFD-induced genes in breast cancer subtypes and association with breast cancer prognosis

From: Analysis of high fat diet induced genes during mammary gland development: identifying role players in poor prognosis of breast cancer

Genea Basal-likeb HER2c Luminal Ad Luminal Be Normal-likef Survival associationg
MMP12 0.17 -0.13* -0.24* -0.19* -0.33* Poor prognosis
GPNMB -0.01 0.00 -0.18* -0.06 -0.11 Poor prognosis
CTSL 0.07 0.04 -0.16* -0.03* -0.18* Poor prognosis
ITGAX 0.00 0.07* 0.04 0.05 0.05 -
LILRB4 0.10 0.02 -0.15* -0.04* -0.22* Poor prognosis
TM7SF1 -0.18 0.05* 0.05* 0.01* -0.03* -
DNMT3A 0.09 0.03 -0.08* 0.00* -0.10* Poor prognosis
TYROBP 0.06 0.01 -0.05* -0.01 -0.13* -
DIO1 -0.21 -0.18 -0.04* -0.01* -0.07* -
SLC11A1 0.14 0.01* -0.10* -0.03* -0.15* Poor prognosis
GALNS 0.05 0.03* 0.01 0.03 0.01 -
NCF2 0.11 0.01* -0.15* -0.04* -0.16* Poor prognosis
PTPNS1 0.23 0.00* -0.15* -0.08* -0.14* Poor prognosis
LGALS3 -0.07 0.04* -0.03 -0.01* 0.04* -
MTHFS -0.02 0.00 0.02 0.05* -0.07 -
IL1RN 0.00 -0.17* -0.13* -0.11 -0.05 -
CTSS 0.12 -0.04* -0.17* -0.06* -0.20* -
WBSCR5 0.03 0.01 0.00 0.00 -0.06* -
PRKCD -0.05 0.02* 0.03* 0.04* -0.02 -
CAPG 0.09 -0.03* -0.06* 0.01* -0.07* -
CD68 0.06 0.09 -0.02* 0.02 -0.01* -
ITGB2 0.11 0.04 -0.09* -0.03* -0.11* Poor prognosis
CSTB 0.18 0.02* -0.04* -0.03* -0.07* Poor prognosis
ATF3 0.01 -0.13* -0.12* -0.09* 0.01 -
CSF2RA 0.01 -0.01 -0.02 -0.01 -0.11* -
WFS1 -0.20 0.00* 0.03* 0.06* -0.02* -
PPGB1 0.00 0.07* -0.05* 0.02 -0.07* Poor prognosis
ADAM8 0.12 0.02* -0.09* -0.06* -0.25* Poor prognosis
CCRL2 0.06 0.07 -0.01 0.02 -0.06* -
VTN 0.00 0.00 0.01 0.01 0.06 -
RGS1 0.04 0.01 -0.03* -0.04* -0.13* -
FCGR3 0.09 0.06 -0.03* 0.03* -0.08* Poor prognosis
EMR1 0.06 -0.03 0.01 0.00* 0.03 -
ARPC2 0.06 0.03 -0.06* -0.03* -0.03* -
ESD -0.04 -0.04 0.02* -0.01 0.08* Good prognosis
VAMP4 0.06 0.05 0.05 0.05 -0.03 -
CDKN1C -0.05 -0.05 -0.05 -0.12 0.13* -
HEXB -0.04 0.00 -0.02 -0.02 -0.03 -
NAGLU -0.01 0.05* 0.02 0.04* 0.12* -
KCNH2 0.00 -0.29* -0.21* -0.15* -0.32* -
MSTF1 0.02 0.03 0.04* 0.04* 0.04 -
  1. aHFD induced genes (Luitjen et al.) that were present in the NKI human breast cancer data set as described in the Methods. b-fAverage gene expression among 5 different human breast cancer subtypes for these genes (Tumors: basal-like n = 46; HER2 n = 49; luminal A n = 88; luminal B n = 81; normal-like n = 31). gTotal of 13 genes associated with poor prognosis and 1 gene associated with good prognosis based on Kaplan Meier survival analysis for the indicated gene with 295 BC samples from the NKI dataset as described in the Materials and Methods. The plots for the genes that were significantly associated with prognosis are depicted in Figure 1 of this manuscript. *Gene expression statistically different with respect to basal-like subtype (False discovery Rate [FDR] < 0.01).