Table 2 Medication use of 901 PD patients
Medication use | Total | Gulf of Bohai | Changjian Delta | Pearl-River Delta | Mid-westArea | P Value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
(n = 901) | (n = 283) | (n = 275) | (n = 110) | (n = 233) | |||||||
LED a | 450 | (350) | 500 | (330) | 435 | (360) | 525 | (353) | 375 | (330) | 0.01 |
LD/DCI treatment, n (%) | 737 | (81.8) | 227 | (80.2) | 231 | (84.0) | 100 | (90.9) | 179 | (76.8) | 0.01 |
LD Dose, mg/d | 375 | (265) | 375 | (200) | 375 | (300) | 375 | (300) | 375 | (250) | 0.81 |
LD/DCI Duration, months b | 29.5 | (51.0) | 36.0 | (54.0) | 34.0 | (51.0) | 21.0 | (45.0) | 16.0 | (38.0) | <0.001 |
Dopamine agonists, n (%) | 296 | (32.7) | 98 | (34.6) | 83 | (30.2) | 53 | (48.2) | 62 | (26.6) | <0.001 |
Duration, months b | 12.0 | (28.0) | 18.0 | (32.0) | 9.5 | (23.0) | 12.0 | (21.0) | 8.0 | (19.5) | 0.004 |
Amantadine, n (%) | 222 | (24.6) | 88 | (31.0) | 77 | (28.0) | 25 | (22.7) | 32 | (13.7) | <0.001 |
Dose, mg/d | 200 | (0) | 200 | (0) | 200 | (100) | 200 | (0) | 200 | (100) | 0.07 |
Duration, months b | 21.0 | (43.0) | 29.5 | (62.5) | 11.0 | (34.0) | 10.5 | (21.5) | 18.5 | (53.5) | 0.002 |
Anticholinergics, n (%) | 169 | (18.8) | 43 | (15.2) | 64 | (23.3) | 15 | (13.6) | 47 | (20.2) | 0.04 |
Dose, mg/d | 4.0 | (2.0) | 4.0 | (3.0) | 3.0 | (2.0) | 4.0 | (4.0) | 4.0 | (4.0) | 0.02 |
Duration, months b | 23.0 | (51.0) | 38.0 | (62.0) | 25.0 | (57.0) | 17.0 | (21.0) | 20.2 | (41.0) | 0.23 |
Entacapone, n (%) | 55 | (6.1) | 17 | (6.0) | 8 | (2.9) | 11 | (10.0) | 19 | (8.2) | 0.02 |
Dose, mg/d | 300 | (200) | 300 | (200) | 250 | (200) | 300 | (200) | 300 | (100) | 0.68 |
Duration, months b | 5.5 | (14.0) | 9.0 | (14.0) | 9.0 | (20.0) | 4.0 | (5.0) | 1.5 | (6.5) | 0.04 |
Selegiline, n (%) | 87 | (9.7) | 36 | (12.7) | 36 | (13.1) | 13 | (11.8) | 2 | (0.9) | <0.001 |
Dose, mg/d | 5.0 | (2.5) | 5.0 | (2.5) | 5.0 | (5.0) | 5.0 | (0.0) | 5.0 | (0.0) | 0.63 |
Duration, months b | 15.0 | (27.0) | 24.0 | (23.0) | 12.0 | (33.0) | 7.5 | (22.0) | 15.0 | (0.0) | 0.87 |
All LD/DCI users (n=737) | |||||||||||
Motor fluctuation, n (%) | 137 | (18.6) | 47 | (20.7) | 50 | (21.6) | 11 | (11.0) | 29 | (16.2) | 0.09 |
Dyskinesias, n (%) | 63 | (8.6) | 22 | (9.7) | 15 | (6.5) | 11 | (11.0) | 15 | (8.4) | 0.49 |