Figure 4

Elasticities of the viral levels to immune response parameters. a, gives the elasticities plot at time 10. Increases in all parameter values result in reduced viral levels. However the chemokine antiviral response which is represented by the parameter h, does not significantly contribute to the control of viral levels. Parameters from the antibody response (h₁,ψ), are predicted to be the best targets for the viral level control. b, gives the elasticities plot at time 30. Parameters from the antibody response have positive elasticity values and thus their increases result in increased viral levels. The lytic antiviral response is predicted to be the best target for the control of viral levels. The parameter values used are given in Table 1 and the initial conditions were $D_0=100,P_0=100,Q_0=100,V_0=100,T_0=750,T_0^{\ast }=100,C_0=1,B_0=1$.