Table 1 Biochemical laboratory results of the patient in relation to time and treatment
Time (At presentation and afterwards) | Serum 25OHD3 [N = 75–250 nmol/L] | Serum 1,25(OH)2D3 [N = 15-75 pg/mL] | Serum PTH [N =1.65–6.9 pmol/L] | Serum Calcium [N = 2.25–2.75 mmol/L] | Serum Phosphorus [N = 1.45–2.16 mmol/L] | Serum Alkaline phosphatase [N = 175–476 IU/L] | Serum Magnesium [N = 0.7–1.1 mmol/L] |
|---|---|---|---|---|---|---|---|
At presentation | 119.5 | 16 | 52.9 | 1.94 | 0.82 | 1682 | 0.7 |
Treatment: She was started with high-dose 1α-hydroxyvitamin D3 (2000 IU/day) and elemental calcium (61 mg/kg/day), it was gradually increased to 150 mg/kg/day with monitoring of serum levels | |||||||
1 month | 99.9 | - | 54.9 | 1.90 | 0.86 | 2027 | - |
Treatment: Addition of oral phosphate supplements. She developed diarrhoea, so it was stopped after 1 week | |||||||
2 months | 99.3 | - | 55.4 | 1.6 | 0.90 | 1276 | - |
Treatment: Continued on 1α-hydroxyvitamin D3 (2000 IU/day) and high-dose of calcium supplements (up to 200 mg/kg/day) | |||||||
3 months | - | - | Initially 14.00 then back to 21.36 | 2.06 | 1.02 | 1358 | - |
Treatment: Started to wean off 1α-hydroxyvitamin D3. The PTH went high again, so it was initial dose was resumed again (2000 IU/day). | |||||||
6 months | - | - | 21.41 | 2.19 | 1.41 | 503 | - |
9 months | - | - | 0.97 | 2.44 | 1.94 | 233 | - |
Treatment: 1α-hydroxyvitamin D3 was weaned off gradually down to (1200 IU/day), with calcium supplements (100 mg/kg/day) | |||||||
10 months | - | - | 0.63 | 2.29 | 2.11 | 222 | 0.7 |
Treatment: Daily Doses settled on 1α-hydroxyvitamin D3 (800 IU/day) and Calcium supplements (80 mg/kg/day) | |||||||