|
Number of helminth infections
|
A. lumbricoides-induced cytokine production
|
|---|
|
n (%)
|
% Non-responders
|
% Responders
|
Crude
|
Adjusted
|
|---|
|
(n)
|
(n)
|
#OR (95% CI)
|
##OR (95% CI)
|
|---|
|
IFN-γ [mean (pg/mL) = 12.3]*
|
| | |
(n = 904)
|
(n = 23)
| | |
|
0
|
416 (44.9)
|
97.1
|
2.9
|
1
|
1
|
|
1
|
342 (36.9)
|
98.0
|
2.0
|
0.70 (0.27; 1.81)
|
0.71 (0.27; 1.87)
|
|
2
|
114 (12.3)
|
97.4
|
2.6
|
0.91 (0.25; 3.28)
|
0.90 (0.24; 3.38)
|
|
3
|
55 (5.9)
|
98.2
|
1.8
|
0.62 (0.08; 4.89)
|
0.64 (0.08; 5.23)
|
|
IL-5 [mean (pg/mL) = 26.6]*
|
| |
(n = 1.013)
|
(n = 139)
| |
|
0
|
530 (46,0)
|
91.3
|
8.7
|
1
|
1
|
|
1
|
422 (36,6)
|
87.7
|
12.3
|
1.47 (0.97; 2.25)
|
1.45 (0.94; 2.23)
|
|
2
|
140 (12,2)
|
82.9
|
17.1
|
2.17 (1.28; 3.71)
|
1.89 (1.09; 3.28)
|
|
3
|
60 (5,2)
|
71.7
|
28.3
|
4.16 (2.20; 7.87)
|
3.54 (1.82; 6.86)
|
|
IL-10 [mean (pg/mL) = 36.3]*
|
| |
(n = 1.205)
|
(n = 51)
| |
|
0
|
568 (45.2)
|
97.4
|
2.6
|
1
|
1
|
|
1
|
461 (36.7)
|
95.1
|
4.9
|
1.93 (1.00; 3.75)
|
1.87 (0.95; 3.66)
|
|
2
|
160 (12.8)
|
93.8
|
6.2
|
2.46 (1.08; 5.58)
|
2.23 (0.96; 5.18)
|
|
3
|
67 (5.3)
|
95.5
|
4.5
|
1.73 (0.49; 6.13)
|
1.43 (0.39; 5.23)
|
|
IL-13 [mean (pg/mL) = 64.5]*
|
| |
(n = 955)
|
(n = 236)
| |
|
0
|
542 (45.5)
|
81.6
|
18.4
|
1
|
1
|
|
1
|
438 (36.8)
|
79.2
|
20.8
|
1.16 (0.84; 1.59)
|
1.18 (0.85; 1.63)
|
|
2
|
147 (12.3)
|
83.0
|
17.0
|
0.91 (0.56; 1.47)
|
0.90 (0.55; 1.48)
|
|
3
|
64 (5.4)
|
68.8
|
31.2
|
2.01 (1.13; 3.56)
|
1.99 (1.10; 3.58)
|
- #Crude logist analysis. ##Logist analysis adjusted for gender, age, maternal education and parental asthma. *Geometric mean; Numbers in bold are statistically significant at P < 0.05 . OR – odds ratio. 95% CI – 95% confidence interval.
