Table 2 Association between methylation status of the MLH1 promoter region and genotypes of the MLH1-93G/A SNP in sporadic colorectal cancers
<Total cases> | Genotype | Allelic frequency | ||||||
|---|---|---|---|---|---|---|---|---|
A/A (n = 54) | A/G (n = 108) | G/G (n = 48) | p values | A | G | RR | p values | |
Methylation-positive | 24 | 26 | 10 | 0.01031 | 74 | 46 | 1.303 | 0.00941 |
Full methylation | 4 | 8 | 1 | 24 | 10 | |||
Partial methylation | 20 | 18 | 9 | 0.02292 | 58 | 36 | 0.00442 | |
Methylation-negative | 30 | 82 | 38 | 142 | 158 | |||
(No methylation) | ||||||||
<Female cases> | Genotype | Allelic frequency | ||||||
A/A (n = 23) | A/G (n = 37) | G/G (n = 22) | p values | A | G | RR | p values | |
Methylation-positive | 14 | 13 | 5 | 0.02591 | 41 | 23 | 1.525 | 0.00671 |
Full methylation | 4 | 5 | 1 | 13 | 7 | |||
Partial methylation | 10 | 8 | 4 | NS2 | 28 | 16 | 0.02232 | |
Methylation-negative | 9 | 24 | 17 | 42 | 58 | |||
(No methylation) | ||||||||
<Male cases> | Genotype | Allelic frequency | ||||||
A/A (n = 31) | A/G (n = 71) | G/G (n = 26) | p values | A | G | RR | p values | |
Methylation-positive | 10 | 13 | 5 | NS1 | 33 | 23 | 1.179 | NS1 |
Full methylation | 0 | 3 | 0 | 3 | 3 | |||
Partial methylation | 10 | 10 | 5 | NS2) | 30 | 20 | NS2) | |
Methylation-negative | 21 | 58 | 21 | 100 | 100 | |||
(No methylation) | ||||||||