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Table 2 Self-diffusion coefficients of the water molecules in breast cancer

From: Dynamic properties of water in breast pathology depend on the histological compounds: distinguishing tissue malignancy by water diffusion coefficients

Parameter

Control n = 6

Breast cancer

Share of stroma*(%) (control + cancer)

The entire group of cancer specimens n = 11

T2N0M0n = 6

T2N1M0n = 5

< 50 n = 14

≥50 n = 3

1

2

3

4

5

6

ADCm · 10−9 (m2/s)

0,78 ± 0,281

1,62 ± 1,28

0,85 ± 0,34

2,54 ± 1,30

0,91 ± 0,28

3,25 ± 0,75

(0,41-1,16)2

(0,33-3,43)

(0,33-1,22)

(0,79-3,43)

(0,41-1,35)

(0,33-3,43)

2,843

10,39

3,69

4,34

3,30

10,39

DFDP · 10−9 (m2/s)

1,25 ± 0,13

0,97 ± 0,25

0,93 ± 0,24

1,01 ± 0,28

1,06 ± 0,27

1,10 ± 0,18

(1,10-1,40)

(0,57-1,25)

(0,60-1,20)

(0,57-1,29)

(0,57-1,40)

(0,90-1,20)

1,27

2,19

2,00

2,25

2,46

1,34

P1 (share)

0,48 ± 0,17

0,75 ± 0,22

0,74 ± 0,28

0,78 ± 0,14

0,69 ± 0,24

0,53 ± 0,26

(0,27-0,77)

(0,23-0,97)

(0,23-0,97)

(0,63-0,95)

(0,27-0,97)

(0,23-0,72)

2,84

4,23

4,22

1,51

3,59

3,14

DSDP · 10−11 (m2/s)

1,67 ± 0,15

0,86 ± 0,68

1,75 ± 0,17

2,00 ± 1,03

1,69 ± 0,16

2,30 ± 1,34

(0,50-1,91)

(0,40-3,84)

(1,50-1,98)

(1,40-3,84)

(1,40-1,98)

(1,50-3,84)

3,82

9,6

1,32

2,74

1,41

2,56

  1. Note: n - number of the samples; 1 – mean value ± SD, 2 - range of parameter.; 3 - ratio of high/low range values of the certain diffusion parameter.
  2. *- crosslinked collagen is embedded into the carbohydrate matrix of stroma.
  3. Comparison of 2 groups (Wilcoxon):
  4. ADCm: 1-2 p<0,03; DFDP: 1-2 p<0,05; P1: 1-2 p>0,15; DSDP: 1-2 p>0,9; 1-3 p>0,9; 1-3 p<0,05; 1-3 p>0,15; 1-3 p>0,3; 1-4 p>0,7; 1-4 p>0,05; 1-4 p<0,05; 1-4 p=1; 1-5 p>0,7; 1-5 p>0,5; 1-5 p>0,05; 1-5 p=1; 1-6 p=1; 1-6 p>0,5; 1-6 p>0,2; 1-6 p=1; 3-4 p>0,2; 3-4 p>0,8; 3-4 p>0,8; 3-4 p>0,5; 5-6 p=1; 5-6 p>0,5; 5-6 p>0,1; 5-6 p=1.