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Table 8 Selected results for TFs that are frequently mutated in cancer

From: A property-based analysis of human transcription factors

Category* Term Observed Expected Pvalue Benjamini MCC
II + IIIAB Acetylation 48 26 1.823E-08 1.46E-07 0.125
  Ubiquitination 47 27 2.08E-07 8.31E-07 0.118
  Methylation 26 11 1.21E-05 3.23E-05 0.110
  PF00856(SET) 6 0 1.21E-05 8.80E-03 0.164
  PF13771(zf-HC5HC2H) 4 0 4.90E-05 1.78E-02 0.175
  PF00628(PHD) 8 1 1.78E-04 2.58E-02 0.114
  Sumoylation 14 5 1.14E-03 2.28E-0 0.082
  O-GlcNAc 5 1 7.03E-03 1.12E-02 0.078
II Acetylation 21 12 1.67E-03 1.33E-02 0.073
  Ubiquitination 20 12 6.61E-03 2.64E-02 0.063
  Methylation 11 5 1.23E-02 3.28E-02 0.062
  O-GlcNAc 3 0 1.89E-02 3.78E-02 0.073
IIIB Sumoylation 5 1 3.51E-03 2.80E-02 0.085
I + IIIAB Ubiquitination 32 16 2.69E-07 2.15E-06 0.114
  Acetylation 30 16 6.44E-06 2.12E-05 0.101
  Methylation 19 7 7.94E-06 2.12E-05 0.114
  PF00856(SET) 5 0 1.67E-05 5.78E-03 0.178
  PF00628(PHD) 7 1 4.70E-05 8.56E-03 0.136
  PF13771(zf-HC5HC2H) 3 0 3.17E-04 2.25E-02 0.168
  Sumoylation 10 3 1.82E-03 3.64E-03 0.082
  DNA_Binding 15 22 9.56E-03 1.53E-02 −0.061
IIIAB Acetylation 27 14 5.47E-06 2.56E-05 0.102
  Ubiquitination 27 14 6.39E-06 2.56E-05 0.101
  PF00628(PHD) 6 0 1.82E-04 2.64E-02 0.125
  PF00439(Bromodomain) 4 0 4.78E-04 4.35E-02 0.132
  Methylation 15 6 2.79E-04 7.44E-04 0.091
  Sumoylation 9 3 2.28E-03 4.56E-03 0.081
  DNA_Binding 12 19 5.45E-03 8.71E-03 −0.065
I Methylation 4 0 5.47E-03 4.38E-02 0.078
  1. *Indicates TFs with similar mutation profiles: I - Mainly mutated across many cancers; II - Highly mutated in a few cancers; IIIA - Highly mutated across many cancers; IIIB - Even more highly mutated across many cancers.