Table 2 Comparison between clinical features, investigation findings and outcome of HSV encephalitis in the general population and those pregnant
Pregnant patients with HSV encephalitis | General population with HSV-1 encephalitis [ 4 ] | p value | General population with HSV encephalitis [ 5 ] | p value | |
|---|---|---|---|---|---|
Fever | 89% (16/18) | 76% (29/38) | 0.75 | 92% (90/98) | 0.22 |
Headache | 67% (12/18) | 42% (16/38) | 0.1 | NK | NK |
Seizures | 45% (8/18) | 63% (24/38) | 0.17 | 32% (31/98) | 0.32 |
Mean GCS on admission (where documented) | 14.6 | NK | NK | 13.7 | NK |
Coma on admission (GCS < 8, where GCS documented) | 0% (0/8) | 24% (9/38) | 0.32 | 9% (9/98) | 0.36 |
Abnormal CT | 40% (4/10) | 56% (18/32) | 1.0 | 79% (72/91) | 0.17 |
(if performed) | |||||
Abnormal MRI | 80% (8/10) | 89% (25/28) | 0.59 | NK | NK |
(if performed) | |||||
Abnormal EEG | 92% (11/12) | 81% (22/27) | 0.64 | NK | NK |
(if performed) | |||||
WCC mean (range) | 177 (0–623) | 46 (10–1278) | 0.51 | 237 (1–3900) | NK |
Death | 3/18 (17%) | 11% (4/38) | 0.67 | 13/85 (15%) | 1.0 |