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Table 2 Quantification of the direction of QTL action in six mouse consomic strain surveys a

From: Chromosomal assignment of quantitative trait loci influencing baseline circulating total cholesterol level in male laboratory mice: report of a consomic strain survey and comparison with published results

Host strain

 

Donor strain

Cohen’s d c

Mouse chromosomes

 

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

X

Y

Reference

    

Quantification direction of QTL action for baseline circulating total cholesterol level, r valueb

 

C57BL/6J

>f

A/J

3.73

0.92

–

–

1.45

d

–

–

0.92

–

0.79

0.68

0.80

d

–

0.75

0.77

0.97

–

–

0.99

1.38

[18]

C57BL/6J

>

A/J

6.00

–

0.24

0.36

0.77

0.63

0.32

–

0.62

–

0.51

0.44

–

–

–

–

–

0.25

0.50

–

0.32

–

[19]

C57BL/6J

=

A/J

0.78

–

–

–

2.86

1.08

–

1.50

1.51

1.04

2.66

1.22

1.86

1.45

1.64

1.80

–

–

–

1.61

1.43

1.68

[20]

C57BL/6J

>

A/J

1.82

−1.33

–

–

d

–

–

−0.67

–

−0.95

–

–

–

–

−0.84

–

−0.75

−0.50

–

−0.48

−0.54

−2.03

[This study]g

C57BL/6J

>

A/J

1.13

−1.03

–

–

d

–

–

–

0.60

–

–

–

0.48

–

−0.36

–

–

–

–

–

–

−1.68

[This study]h

C57BL/6J

<

PWD/PhJ

1.06

d

–

d

d

–

–

d

d

d

d

−1.00e

−

d

–

d

–

–

−1.96

1.36

1.18e

–

[64]

C57BL/6J

=

MSM/Ms

1.44

–

2.12e

3.99

2.99

4.23

–

–

–

–

d

–

1.41e

–

–

–

–

–

3.15

–

3.01e

–

[65]

               

2.51e

       

2.36e

  
  1. aOnly the results from male mice are presented.
  2. bAccording to Shao et al. [66] a variable r was calculated to quantify the direction of QTL action, in terms of ‘moving toward’ or ‘away from’ the mean trait value (T) for the donor strain, where r = (THost – TCSS)/(THost – TDonor), and where THost, TCSS, and TDonor were the mean values for baseline circulating total cholesterol level in the corresponding strains. When 0 < r < 1, the substituted chromosome shifted the phenotypic trait values towards the donor strain (i.e. were in the range between the two parental strains), whereas when r < 0 or r > 1, the substitutions moved the trait values away from the donor strain (i.e. were outside the range between the parental strains).
  3. cThe Cohen’s d score is here defined as the difference between the means for the two parental strains divided by the pooled SD.
  4. dThis consomic line was not tested or has not been established.
  5. eBased on a sub-consomic strain.
  6. f‘>‘ means: male host strain mice compared to male donor strain mice had a significantly higher baseline circulating total cholesterol level; ‘<‘ means: male host strain mice compared to male donor strain mice had a significantly lower baseline circulating total cholesterol level; ‘=‘ means: baseline circulating total cholesterol level from male host and donor strain mice are not significantly different.
  7. gBased on unadjusted means.
  8. hBased on means adjusted for four covariates (‘body weight at arrival’, ‘age at blood sampling’, ‘blood collection period’, and ‘time of the day blood was collected’).
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BMC Research Notes

ISSN: 1756-0500

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