Relationship between daily losartan requirements for the 2003-2014 period and corresponding maximum environmental temperatures. The third order regressions through data points (e.g. Figures 7, 8) are shown for each year. Line colouring for different years follows that of Figure 6. Consecutive r2 values for 2011–2014 were 0.22, 0.38, 0.34, and 0.45.