From: Eosinophilic esophagitis associated with celiac disease in children
Clinical characteristics | CD (n = 50) mean ± SD or n (%) | CD and EoE (n = 6) mean ± SD or n (%) | P value |
---|---|---|---|
Demographics | |||
Age at diagnosis (years) | 10.5 ± 4.3 | 11.6 ± 1.6 | 0.536 |
Gender | |||
Male/Female | 17 (34)/33 (66) | 5 (83)/1 (17) | 0.030 |
Race | |||
Caucasian/Other | 48 (96)/2 (4) | 5 (83)/1 (17) | 0.293 |
Duration of symptoms (months) | 13.8 ± 14.6 | 15.9 ± 12.2 | 0.738 |
History of allergies | |||
Asthma | 2 (4) | 1 (17) | 0.293 |
Food allergy | 8 (16) | 4 (67) | 0.016 |
Presenting symptoms | |||
Abdominal pain | 27 (54) | 4 (67) | 0.682 |
Dysphagia | 0 (0) | 1 (17) | 0.107 |
Failure to thrive | 12 (24) | 3 (50) | 0.326 |
Diarrhea/Constipation | 18 (36) | 0 (0) | 0.162 |
Endoscopy findings | |||
Normal esophagus | 50 (100) | 0 (0) | <0.0005 |
Ringed esophagus | 0 (0) | 1 (17) | 0.035 |
Esophageal mucosal furrows | 0 (0) | 5 (85) | 0.0005 |
White plaques in esophagus | 0 (0) | 4 (67) | 0.001 |
Normal duodenum | 24 (48) | 4 (67) | 0.669 |
Scalloping duodenum | 25 (50) | 2 (33) | 0.671 |
Histopathological findings | |||
TTG IgA (U/mL) | 164.4 ± 129.2 | 248.7 ± 82.4 | 0.058 |
Esophageal eosinophilia | 1.1 ± 2.4 | 42 ± 20 | 0.0001 |
Marsh score | – | ||
1 | 8 (16) | 0 (0) | |
2 | 8 (16) | 2 (33) | |
3a | 16 (32) | 0 (0) | |
3b | 18 (36) | 4 (67) |