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Table 2 Results for 0–18 weeks GWG adjusted for maternal age and child’s sex

From: Effect of maternal gestational weight gain on offspring DNA methylation: a follow-up to the ALSPAC cohort study

Gene (# CpG’s) GoldenGate CpG Closest CpG Coef Se GWG p value (adjusted) GWG q value (450K) GWG q value (GG)
MMP7* (7) cg10521988 cg04059146 0.00706 0.00466 0.1300039 (0.9100273) 0.9198694 0.9244006
MMP7 (7) cg20645973 cg20645973 −0.00141 0.005456 0.7955276 (~1.0) 0.9600729 0.9720421
KCNK4 (26) cg01352108 cg01352108 −0.00794 0.004879 0.1041649 (~1.0) 0.9198694 0.9244006
KCNK4 (26) cg25881850 cg25881850 −0.00386 0.004814 0.4233765 (~1.0) 0.9373223 0.9244006
TRPM5 (46) cg01581060 cg01581060 −0.00152 0.004361 0.7282958 (~1.0) 0.9568195 0.9720421
TRPM5* (46) cg03982381 cg04691795 −0.01572 0.00626 0.0122687 (0.5643602) 0.9198694 0.9244006
TRPM5* (46) cg19265431 cg10172068 −0.02234 0.012938 0.012938 (0.595148) 0.9198694 0.9244006
NFKB1* (19) cg06930505 cg00790535 −0.0176 0.007064 0.0129537 (0.2461203) 0.9198694 0.9244006
NFKB1* (19) cg24413435 cg12615753 0.00936 0.006383 0.1430112 (~1) 0.9198694 0.9244006
  1. The table shows coefficient estimates (Coef), standard errors (Se) and p/q value estimations for the CpG loci linked to the genes found significantly differentially methylated in the ALSPAC study. The p values are “raw” in the sense that they are unadjusted for multiple testing; p values Bonferroni-adjusted for multiple testing according to the number of CpG’s on the Illumina Humanmethylation450 platform associated with each respective gene is included in brackets. The q values were based on multiple test corrections performed for both the HumanMethylation450 platform [GWG q value (450K), 473,731 tests] and the Golden Gate platform [GWG q value (GG) 1,505 tests]. CpGs marked with * were not directly observed but flanking markers are reported which were associated within the gene body (all *-marked CpG’s linked to the NFKB1 and TRPM5 genes) and promoter regions (*-marked CpG linked to the MMP7 gene).
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