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Table 5 Mean area under curve of Chi8 and GBOOST on simulated GWAS of 1600 subjects

From: Chi8: a GPU program for detecting significant interacting SNPs with the Chi-square 8-df test

Allele freq. 0.1 0.2 0.4
Model 1
 Chi8 0.56 0.15 0.04
 GBOOST 0.43 0.54 0.22
Model 2
 Chi8 0.46 0.98 0.97
 GBOOST 0.49 0.98 0.98
Model 3
 Chi8 0.68 0.65 0.93
 GBOOST 0.37 0.62 0.97
Model 4
 Chi8 0.35 0.89 1
 GBOOST 0.43 0.98 0.98
  1. To account for Chi8’s sensitivity to univariate significant SNPs we only consider reported pairs where both SNPs are also individually insignificant