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Table 2 Baseline characteristics by antibiotic

From: Risk factors for kidney injury during vancomycin and piperacillin/tazobactam administration, including increased odds of injury with combination therapy

Baseline patient characteristic Vancomycin (N = 101) Piperacillin–tazobactam (N = 26) Combination (N = 101) p value (vanc vs piptazo) p value (vanc vs combV/P) p value (piptazo vs combV/P) p value (overall)
Age: mean (sd) 47.00 (15.85) 47.58 (13.22) 50.71 (15.11)     0.21
Female sex (%) 39 (38.61 %) 9 (34.62 %) 32 (31.68 %)     0.59
African American (%) 84 (83.17 %) 16 (61.54 %) 82 (81.19 %) 0.02* 0.71 0.03* 0.04
CrCl in ml/min: mean (sd) 79.61 (36.35) 75.33 (36.12) 68.22 (26.70)     0.08
Number of nephrotoxic agents        0.98
 0 agent 63 (63.00 %) 17 (65.38 %) 64 (63.37 %)     
 1 agent 29 (29.00 %) 6 (23.08 %) 31 (30.69 %)     
 2 agents 6 (6.00 %) 3 (11.54 %) 6 (5.94 %)     
 3 agents 2 (2.00 %) 0 0     
Number of comorbidities     0.26 0.0012* 0.0026* 0.0006
 0 46 (45.54 %) 16 (61.54 %) 26 (25.74 %)     
 1 34 (33.66 %) 5 (19.23 %) 36 (35.64 %)     
 2 17 (16.83 %) 4 (15.38 %) 34 (33.66 %)     
 3 4 (3.96 %) 1 (3.85 %) 5 (4.95 %)     
BMI: mean (sd) 26.75 (9.72) 30.27 (10.05) 26.07 (8.23)     0.20
IV contrast 23 (22.77 %) 3 (11.54 %) 24 (23.76 %)     0.39
Aminoglycoside 5 (4.95 %) 0 3 (2.97 %)     0.44
NSAID 13 (13.00 %) 9 (34.62 %) 9 (8.91 %) 0.0097* 0.35 0.0008* 0.003
Tenofovir 6 (5.94 %) 0 7 (6.93 %)     0.39
Diabetes 16 (15.84 %) 3 (11.54 %) 30 (29.70 %) 0.58 0.02* 0.06 0.02
Hypertension 32 (31.68 %) 10 (38.46 %) 49 (48.51 %) 0.51 0.01* 0.36 0.05
Malignancy 5 (4.95 %) 2 (7.69 %) 9 (8.91 %)     0.54
CKD 5 (4.95 %) 0 7 (6.93 %)     0.36
HIV 22 (21.78 %) 1 (3.85 %) 27 (26.73 %) 0.03* 0.41 0.01* 0.04
Indication for antibiotics        
Pneumonia 15 (14.85 %) 1 (3.85 %) 28 (27.72 %) 0.1899 0.03* 0.0097* 0.0072
bacteremia 5 (4.95 %) 0 2 (1.98 %)     0.46
SSTI 40 (39.60 %) 4 (15.38 %) 32 (31.68 %)     0.06
Abdominal 1 (0.99 %) 15 (57.69 %) 4 (3.96 %) <0.0001* 0.37 <0.0001* <0.0001
CNS 2 (1.98 %) 0 0     0.61
UTI 3 (2.97 %) 5 (19.23 %) 1 (0.99 %) 0.0091* 0.62 0.0013* 0.0003
Bone or joint infection 25 (24.75 %) 0 16 (15.84 %) 0.0046* 0.11 0.04* 0.01
Sepsis of unknown etiology 10 (10.20 %) 1 (4.55 %) 15 (15.00 %)     0.31
  1. P < 0.05 between individual groups denoted by italics and asterisk