Skip to main content

Advertisement

Table 2 Demographics, clinical staging, treatments, PLK1 mRNA and FOXM1 mRNA expression of the patients in each tissue group

From: FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas

  Gastric normal Gastric adenocarcinoma
Number of cases 13 8 (1HGD)
Male 4 (31) 7 (88) (p = 0.02)
Age 72 ± 3 70 ± 4 (p = 0.45)
Smoking
 Never 1 (8) 1 (11) (p = 0.45)
 Ex-smoker 1 (8) 2 (22) (p = 0.98)
 Current 5 (38) 6 (67) (p = 0.09)
 Missing 6 (46) 0
Pathological differentiation
 Poor   6 (75)
 Moderate   0
 Well   0
 Missing   2 (25)
Depth of invasion
 T1   1 (13)
 T2   2 (25)
 T3   3 (50)
 T4   0
Missing   1 (13)
Metastatic disease
 Local (N)   3 (37.5)
 Distant (M)   0 (0)
AJCC 2010 Stage
 1   2 (25)
 2   3 (36)
 3   2 (25)
 4   0
 Missing   1 (13)
Treatment
 Surgery   6 (75)
 Surgery and chemotherapy   1 (13)
 Chemotherapy   0
 Chemo-radiotherapy   0
 EMR   0
 Palliative care   1 (13)
 Missing   0
PLK1 mRNA expression
 mRNA level ×10 2.1 18.8
 Positive expression 2 (15) 5 (63) (p = 0.056)
FOXM1 mRNA expression
 mRNA level ×10 1.2 9.2
 Positive expression 0 (0) 6 (75) (p = 0.001)
  1. The number of cases is shown in each category, percentages are in brackets. mRNA levels are mean expression levels and standard deviation relative to 18S ribosomal RNA and standards derived from HET1a cell lines. The number of patients with clinical data missing is indicated. Positive expression is defined as an expression level equal or higher to the mean of the normal sample plus two standard deviations about the mean for the indicated gene. P values calculated by Chi2 test are indicated
  2. HGD high grade dysplasia, EMR endoscopic mucosal resection