Skip to main content

Table 2 Details of SNPs found in innate immune genes at 10× coverage using SSTE kit which have been associated with susceptibility to TB [4]

From: Preliminary evaluation of exome sequencing to identify genetic markers of susceptibility to tuberculosis disease

Gene Polymorphism SNP Coding change Amino acid change Genetic location Active cases Latent cases
TLR1 rs4833095 743A > G Asn248Ser Exon 3 0
rs5743618 1805G > T Ser602Ile Exon 3 0
TLR8 rs3764880 1A > G Met1Val   2 1
TLR9 rs352143 169A > G Asn57Asp   1 1
TIRAP rs8177374 539C > T Ser180Leu   0 1
NOD2 rs2066842 802C > T Pro268Ser Exon 0 1
rs2066844 2104C > T Arg702Trp Exon 0 1
VDR rs2228570 2T > C Met1   3 2
rs731236 (TaqI) 1056T > C   Coding-synon 1 0
ILIB rs1143634 315C > T   Coding-synon 0 1
TNF rs1800629 −308G/A   Promoter 1 0
  1. Multiple SNPs that have not been previously reported to be associated with susceptibility to TB were found in all of these genes