|
Gene
|
Polymorphism SNP
|
Coding change
|
Amino acid change
|
Genetic location
|
Active cases
|
Latent cases
|
|---|
|
TLR1
|
rs4833095
|
743A > G
|
Asn248Ser
|
Exon
|
3
|
0
|
|
rs5743618
|
1805G > T
|
Ser602Ile
|
Exon
|
3
|
0
|
|
TLR8
|
rs3764880
|
1A > G
|
Met1Val
| |
2
|
1
|
|
TLR9
|
rs352143
|
169A > G
|
Asn57Asp
| |
1
|
1
|
|
TIRAP
|
rs8177374
|
539C > T
|
Ser180Leu
| |
0
|
1
|
|
NOD2
|
rs2066842
|
802C > T
|
Pro268Ser
|
Exon
|
0
|
1
|
|
rs2066844
|
2104C > T
|
Arg702Trp
|
Exon
|
0
|
1
|
|
VDR
|
rs2228570
|
2T > C
|
Met1
| |
3
|
2
|
|
rs731236 (TaqI)
|
1056T > C
| |
Coding-synon
|
1
|
0
|
|
ILIB
|
rs1143634
|
315C > T
| |
Coding-synon
|
0
|
1
|
|
TNF
|
rs1800629
|
−308G/A
| |
Promoter
|
1
|
0
|
- Multiple SNPs that have not been previously reported to be associated with susceptibility to TB were found in all of these genes
