Table 2 Details of SNPs found in innate immune genes at 10× coverage using SSTE kit which have been associated with susceptibility to TB [4]
Gene | Polymorphism SNP | Coding change | Amino acid change | Genetic location | Active cases | Latent cases |
|---|---|---|---|---|---|---|
TLR1 | rs4833095 | 743A > G | Asn248Ser | Exon | 3 | 0 |
rs5743618 | 1805G > T | Ser602Ile | Exon | 3 | 0 | |
TLR8 | rs3764880 | 1A > G | Met1Val | 2 | 1 | |
TLR9 | rs352143 | 169A > G | Asn57Asp | 1 | 1 | |
TIRAP | rs8177374 | 539C > T | Ser180Leu | 0 | 1 | |
NOD2 | rs2066842 | 802C > T | Pro268Ser | Exon | 0 | 1 |
rs2066844 | 2104C > T | Arg702Trp | Exon | 0 | 1 | |
VDR | rs2228570 | 2T > C | Met1 | 3 | 2 | |
rs731236 (TaqI) | 1056T > C | Coding-synon | 1 | 0 | ||
ILIB | rs1143634 | 315C > T | Coding-synon | 0 | 1 | |
TNF | rs1800629 | −308G/A | Promoter | 1 | 0 |