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Table 1 Demographic data for overall study population and high and low-MPR subgroups

From: Effect of late sodium current inhibition on MRI measured diastolic dysfunction in aortic stenosis: a pilot study

Parameter Overall (n = 15) Low-MPR (n = 7) High-MPR (n = 8)
Age (years) 65.9 ± 9.67 63.6 ± 10.3 67.9 ± 9.3
Gender ratio (male/female, n (%)) 12/3 (80.0/20.0) 6/1 (85.7/14.3) 6/2 (75.0/25.0)
BMI (kg/m2) 29.3 ± 3.36 29.3 ± 4.3 29.3 ± 2.6
Heart rate (bpm) 74.5 ± 11.8 78.6 ± 9.4 71.0 ± 13.2
Systolic blood pressure (mmHg) 153.0 ± 23.6 153.0 ± 29.3 153.0 ± 19.6
Diastolic blood pressure (mmHg) 81.7 ± 11.1 83.7 ± 11.3 80.0 ± 11.4
Echocardiographic Data
 Peak pressure gradient (mmHg) 48.8 ± 12.4 50.5 ± 13.0 49.2 ± 12.7
 Mean pressure gradient (mmHg) 27.1 ± 7.5 27.4 ± 7.5 27.0 ± 8.1
 Aortic valve area (cm2) 1.26 ± 0.31 1.31 ± 0.40 1.20 ± 0.21
 E/A 0.77 ± 0.16 0.79 ± 0.17 0.76 ±0.17
 Average septal E/e’ 12.94 ± 3.91 11.19 ± 1.01 14.48 ± 4.89
 Average lateral E/e’ 10.65 ± 3.49 9.34 ± 2.90 11.80 ± 3.73
 Resting LVRPP (mmHg.bpm) 14,424.3 ± 3054.0 15,400.5 ± 2627.3 13,570.2 ± 3309.1
 Exercise LVRPP (mmHg.bpm) 36,041.3 ± 5235.1 38,888.7 ± 4365.0 34,449.0 ± 5656.8
CMR data
 LVMI (g/m2) 66.72 ± 15.35 68.2 ± 13.9 65.4 ± 17.3
 LVEDVI (ml/m2) 85.02 ± 15.92 81.59 ± 17.33 88.03 ± 15.07
 LVEF (%) 58.29 ± 3.81 58.3 ± 3.3 58.3 ± 4.4
  1. BMI body mass index, LVRPP left ventricular rate pressure product, LVMI left ventricular mass indexed to body surface area, LVEDVI left ventricular end diastolic volume indexed to body surface area, LVEF left ventricular ejection fraction
  2. Independent t test used to compare low and high-MPR subgroups