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Table 4 Cox proportional models for prognostic factors

From: The best objective response of target lesions and the incidence of treatment-related hypertension are associated with the survival of patients with metastatic renal cell carcinoma treated with sunitinib: a Japanese retrospective study

Variables Progression-free survival Overall survival
HR 95 % CI P value HR 95 % CI P value
Best objective response on target lesions
 CR/PR 1    1   
 SD 1.67 0.61–4.60 0.23 4.51 0.95–21.4 0.06
 PD 1.88 0.52–6.84 0.09 7.93 1.36–47.8 0.02
 NE 3.56 1.00–12.9 0.05 4.88 1.02–23.2 0.04
Heng risk group
 Favorable 1    1   
 Intermediate 2.70 0.97–7.56 0.06 2.69 0.61–11.9 0.19
 Poor 14.50 4.42–48.0 0.001 10.1 2.03–50.6 0.01
Serum CRP level (mg/dL)
 ≤0.3 1    1   
 0.3< 1.68 0.72–3.96 0.23 1.50 0.58–3.91 0.40
Serum sodium level (mmol/L)
 ≥135 NA 1   
 135> 1.65 0.63–4.30 0.31
Hypertension related to sunitinib
 Yes 1    NA
 No 3.14 1.55–6.36 0.002
  1. HR hazard ratio; CI confience interval; CR complete response; PR pertial response; SD stable disease; PD progressive disease; NE not evaluable; MSKCC Memorial Sloan Kettering Cancer Center; CRP C-reactive protein; NA not analyzed