Automated PGP9.5 immunofluorescence staining: a valuable tool in the assessment of small fiber neuropathy?

BMC Research Notes

Table 2 Comparing GS-EFNS and LDT for assessing nerve fiber density in skin biopsies of SFN patients

	GS-EFNS	LDT	Mean diff.	P
IENF	1.12 ± 1.65	0.89 ± 1.35	0.23	0.42
IENF_Si	0.55 ± 0.56	0.71 ± 0.95	−0.16	0.42
IENF_Br	0.57 ± 1.16	0.18 ± 0.43	0.39	0.09
IENF_F	0.38 ± 0.84	0.66 ± 1.16	−0.29	0.25
IENF_FSi	0.23 ± 0.49	0.46 ± 0.76	−0.23	0.30
IENF_FBr	0.15 ± 0.35	0.21 ± 0.41	−0.06	0.17
Total ENF	1.50 ± 2.46	1.56 ± 2.48	−0.06	0.42

Diff difference, ENF epidermal nerve fiber, GS-EFNS gold standard method according to EFNS, IENF intra-epidermal nerve fiber, IENF_Si intra-epidermal nerve fiber crossing dermal-epidermal junction as single fiber, IENF_Br intra-epidermal nerve fiber crossing dermal-epidermal junction as fiber showing branching, IENF_F nerve fiber fragment lying free in epidermis, IENF_FSi nerve fiber fragment lying free in epidermis as single fragment, IENF_FBr nerve fiber fragment lying free in epidermis showing branching, LDT laboratory developed test

ISSN: 1756-0500