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Table 2 Comparing GS-EFNS and LDT for assessing nerve fiber density in skin biopsies of SFN patients

From: Automated PGP9.5 immunofluorescence staining: a valuable tool in the assessment of small fiber neuropathy?

  GS-EFNS LDT Mean diff. P
IENF 1.12 ± 1.65 0.89 ± 1.35 0.23 0.42
 IENF_Si 0.55 ± 0.56 0.71 ± 0.95 −0.16 0.42
 IENF_Br 0.57 ± 1.16 0.18 ± 0.43 0.39 0.09
IENF_F 0.38 ± 0.84 0.66 ± 1.16 −0.29 0.25
 IENF_FSi 0.23 ± 0.49 0.46 ± 0.76 −0.23 0.30
 IENF_FBr 0.15 ± 0.35 0.21 ± 0.41 −0.06 0.17
Total ENF 1.50 ± 2.46 1.56 ± 2.48 −0.06 0.42
  1. Diff difference, ENF epidermal nerve fiber, GS-EFNS gold standard method according to EFNS, IENF intra-epidermal nerve fiber, IENF_Si intra-epidermal nerve fiber crossing dermal-epidermal junction as single fiber, IENF_Br intra-epidermal nerve fiber crossing dermal-epidermal junction as fiber showing branching, IENF_F nerve fiber fragment lying free in epidermis, IENF_FSi nerve fiber fragment lying free in epidermis as single fragment, IENF_FBr nerve fiber fragment lying free in epidermis showing branching, LDT laboratory developed test