Skip to main content

Table 2 Patient characteristics, treatment and outcome

From: Clinical features and treatment outcomes of septic arthritis due to Mycobacterium massiliense associated with intra-articular injection: a case report

Patient number

Sex/age

Past history

Injection count

Incubation period (weeks)a

Antibiotics and surgeriesb

Outcome (range of motion)

1e

F/54

Breast cancer

Six

4

Cefazolin (2 days)

Ceftazidime (8 days) + vancomycin (3 days) → ceftazi dayime + teicoplanin (2 days)

Amikacin (68 days) + imipenem (81 days) + clarithromycin (184 day)

Arthroscopic irrigation and debridement (X2)

Brisement

Readmission due to knee abscess

 Imipenem (8 days) + clarithromycin (137 days)

 Arthroscopic irrigation and debridement

 Incision and drainage of knee abscess

Rt. 0–120

Lt. 0–120

2

F/51

Hypertension

Six

4

Cefazolin (2 days)

Ceftazidime (7 days) + vancomycin (7 days)

Amikacin (30 days) + imipenem (110 days) + clarithromycin (171 days)

Arthroscopic irrigation and debridement (X2)

Incision and drainage (X3) of back, buttock abscesses

Arthroscopic irrigation and debridement

Brisement (X2)

Arthroscopic adhesiolysis

Readmission due to thigh, calf abscesses

 Imipenem (12 days) + clarithromycin (92 days)

 Incision and drainage of abscesses

Full

3

F/56

Diabetes mellitus

Two

6

Cefazolin (4 days)

Ceftazidime (3 days) + vancomycin (3 days)

Amikacin (34 days) + imipenem (80 days) + clarithromycin (174 days)

Arthroscopic irrigation and debridement (X3)

Arthroscopic adhesiolysis

Brisement

Open excision of back abscess

Full

4

F/65

Diabetes mellitus

Multiple

(above eight)

7

Cefazolin (1 day)

Ceftazidime (2 days) + vancomycin (2 days)

Amikacin (29 days) + imipenem (81 days) + clarithromycin (399 days)

Arthroscopic irrigation and debridement (X2)

Excision of thigh abscess

Incision and drainage of back abscess

Full

5

F/59

Subclinical hypothyroidism

Four

3

Cefazolin (1 day)

Ceftazidime (3 days) + vancomycin (3 days)

Amikacin (27 days) + imipenem (81 days) + clarithromycin (100 days)

Arthroscopic irrigation and debridement (X2)

Arthroscopic adhesiolysis

Brisement

Readmission due to recurrence of septic arthritis and buttock abscess

 Imipenem (25 days) + clarithromycin (160 days)

 Arthroscopic irrigation and debridement

 Incision and drainage of buttock abscess

Full

6f

F/63

Hyperlipidemia

Osteoarthritis

Fivec

2

Ceftazidime (3 days) + vancomycin (3 days)

Amikacin (29 days) + imipenem (46 days) + clarithromycin (321 days)

Arthroscopic irrigation and debridement

Rt. 0–125

7g

M/61

Psoriasis

Septic arthritis

Two

5–9 (assumedd)

Ceftazidime (1 day) + vancomycin (1 day)

Amikacin (27 days) + imipenem (233 days) + clarithromycin (253 days)

Arthroscopic irrigation and debridement (X5)

Incision and drainage (X5) of popliteal fossa, both buttock, thigh and knee abscesses

Brisement

Excision of thigh, knee abscesses

Rt. 0–125

Lt. 0–120

8

F/71

Hypertension

Diabetes mellitus

Herniated intervertebral disc

Multiple (above six)

3

Cefazolin (1 day)

Ceftazidime (3 days) + vancomycin (3 days)

Amikacin (16 days) + imipenem (71 days) + clarithromycin (117 days)

Arthroscopic irrigation and debridement

Excision and revision of necrotic wounds of neck, back

Debridement of back abscess

Arthroscopic irrigation and debridement

Incision and drainage of neck, back abscesses

Readmission due to abscesses of multiple sites

 Imipenem (34 days) + clarithromycin (98 days)

 Arthroscopic irrigation and debriment

 Incision and drainage of neck, back, buttock and leg abscesses

Outpatient clinic follow up due to abscesses of multiple sites

 Imipenem (15 days) + clarithromycin (62 days) + levofloxacin (28 days)

Readmission due to Rt. leg, back abscesses

 Imipenem (25 days) + clarithromycin (29 days)

 Incision and drainage, excision of abscesses

Outpatient clinic follow up due to abscesses of multiple sites

 Clarithromycin (77 days) + linezolid (57 days)

 Amikacin (20 days) + imipenem (20 days) + clarithromycin (294 days)

 Clarithromycin (99 days) + doxycycline (99 days)

Full

9h

F/49

Osteoarthritis

Multiple

5–8 (presumedd)

Amikacin (6 days) + imipenem (67 days) + clarithromycin (67 days)

Arthroscopic irrigation and debridement

Brisement

Cefoxitin (48 days) + clarithromycin (164 days)

Arthroscopic irrigation and debridement

Incision and drainage of knee abscess

Clarithromycin (88 days) + linezolid (14 days)

Readmission due to recurrence of septic arthritis

Cefoxitin (13 days) + amikacin (13 days) + clarithromycin (182 days)

Readmission due to knee abscess and recurrence of septic arthritis

 Cefoxitin (38 days) + amikacin (38 days) + clarithromycin (178 days) + [ciprofloxacin (9 days) → levofloxacin (148 days)]

 Excision of knee abscess

Full

  1. a Incubation period means time between exposure to first injection and appearance of the first symptoms
  2. b We list antibiotics before and surgeries later with a number in the order, and assign new number if patient readmitted. We indicate duration of antibiotics and number of surgeries in parenthesis. The alphabet “d” in parenthesis following antibiotics is abbreviation for day
  3. c The patient had four injections by the original clinic and one injection by a different private clinic after the onset of symptoms
  4. d Patients could not recall the exact onset of the symptoms and recalled on a monthly basis rather than weekly. So we set incubation period from the first week to last week on the basis of their memory
  5. e Vancomycin was stopped due to drug fever and was replaced by teicoplanin
  6. f Small abscesses of both knees appeared when the patient followed up observations in an outpatient setting. We recommended her admission but she refused
  7. g The patient was discharged against medical advice and did not return due to financial limitations
  8. h The patient was treated with isoniazid, rifampin, ethambutol and pyrazinamide for 6 days at another hospital before visiting our hospital. We changed imipenem to cefoxitin because of nausea, vomiting. The patient was further readmitted twice due to postoperative pus discharge and knee abscess recurrence in spite of maintenance of oral clarithromycin and ciprofloxacin replaced with levofloxacin