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Table 1 Sequences of novel BK analogs with N-terminal extensions compared to that of parent peptides in each category (italicized names)

From: Infrared-emitting, peptidase-resistant fluorescent ligands of the bradykinin B2 receptor: application to cytofluorometry and imaging

Peptide Position Binding competition IC50 nM (95 % C.L.)
−1 0 1 2 3 4 5 6 7 8 9
B2 receptor agonists
 First parent peptide: BK    Arg Pro Pro Gly Phe Ser Pro Phe Arg-COOH 8.2 (6.0–11.2)
 Second parent peptide: B-9972   D-Arg Arg Pro Hyp Gly Igl Ser Oic Igl Arg-COOH 17.3 (13.3–22.4)
 B-10666 = Cy7-B-9972 Cy7 D-Arg Arg Pro Hyp Gly Igl Ser Oic Igl Arg-COOH 598 (481–742)
B2 receptor antagonists
 Parent peptide: B-9430   D-Arg Arg Pro Hyp Gly Igl Ser D-Igl Oic Arg-COOH 42.6 (20.0–90.8)
 B-10665 = Cy7-B-9430 Cy7 D-Arg Arg Pro Hyp Gly Igl Ser D-Igl Oic Arg-COOH 25.7 (11.5–57.1)
  1. Cy7, cyanine dye 7; Hyp, trans-4-hydroxyproline; Igl, α-(2-indanyl)glycine; Oic, (3as, 7as)-octahydroindole-2-carboxylic acid; Tic, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid