Fig. 3
From: A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy
Inhibition of Pdxk in the α-synuclein-induced PD model does not alter phenotypes. a The inhibition of Pdxk with α-synuclein in the Ddc-Gal4-expressing neurons showed no significant change in lifespan when compared to the control. Genotypes are UAS-α-synuclein; Ddc-Gal4/UAS-lacZ and UAS-α-synuclein; Ddc-Gal4/Pdxk-RNAi. Longevity is shown as percent survival [P < 0.05, determined by log-rank (Mantel–Cox) test with n ≤ 200]. b The co-expression of Pdxk-RNAi in the α-synuclein model of PD did not result in any significant age-dependent loss in climbing ability compared to the control. The genotypes are UAS-α-synuclein; Ddc-Gal4/UAS-lacZ and UAS-α-synuclein; Ddc-Gal4/Pdxk-RNAi. Analysis was done by nonlinear fitting of the climbing curves and significance was determined by comparing the 95% confidence intervals. Error bars indicate SEM and n = 50