Fig. 2

The effect of SNE (100–1000 mg/kg, p.o) and PGB (10–100 mg/kg, p.o) on thermal hyperalgesia in paclitaxel-induced neuropathy in rats. The left panels represent a time-course effects of SNE (a) and PGB (c) on day 8 after the induction of the neuropathy. The right panels also represent the total antinociceptive effects (calculated from the AUCs) of SNE (b) and PGB (d). Data are mean ± SEM (n = 5). *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001 compared to vehicle group (two-way ANOVA followed by a Bonferroni’s posthoc test). ^†P ≤ 0.05, ^††P ≤ 0.01 and ^†††P ≤ 0.001 compared to vehicle group (one-way ANOVA followed by a Dunnett’s multiple comparison test)