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Table 2 Distribution of mean values of different measures of insulin resistance/sensitivity according to different status of anthropometric and metabolic measures

From: Insulin resistance in a cohort of 5–15 year old children in urban Sri Lanka

Anthropometric/metabolic

Measure of insulin resistance/sensitivity

Parameter

Status

Fasting insulin

2 h post glucose insulin

HOMA_IR

QUICKY

FIGR

HOMA–B¥

35.52 ± 39.0

212.91 ± 273.37

1.02 ± 1.14

0.41 ± 0.05

6.41 ± 7.04

177.86 ± 533.22

BMI§,† (kgm−2)

Lean

30.27 ± 34.09

172.53 ± 204.11

0.87 ± 1.01

0.42 ± 4.59

0.54 ± 6.12

161.84 ± 566.44

Over weight

54.58 ± 32.5

435.68 ± 428.47

1.57 ± 0.96

0.37 ± 4.49

9.80 ± 5.76

225.12 ± 215.56

Obese

89.54 ± 77.82

437.76 ± 520.54

2.55 ± 2.21

0.35 ± 4.27

0.16 ± 0.14

372.27 ± 401.62

WC‡ (cm)

Normal

27.85 ± 33.87

142.20 ± 139.32

0.80 ± 0.99

0.42 ± 4.41

5.06 ± 6.06

157.19 ± 606.81

High

53.31 ± 44.23*

378.14 ± 407.74*

1.54 ± 1.28*

0.38 ± 4.69*

0.10 ± 8.11*

225.88 ± 296.73

DBP (mmHg)

Normal

33.56 ± 32.52

192.95 ± 222.51

0.96 ± 0.95

0.41 ± 4.81

6.07 ± 5.94

174.75 ± 544.42

High

63.72 ± 87.98*

499.33 ± 605.00*

1.85 ± 2.56*

0.39 ± 6.10*

0.11 ± 0.16*

222.88 ± 337.87

CHO (mmol/l)

Normal

36.14 ± 42.14

213.36 ± 285.08

1.03 ± 1.21

0.41 ± 4.91

6.58 ± 7.70

200.59 ± 584.77

High

33.10 ± 26.82

207.61 ± 233.74

0.98 ± 0.87

0.41 ± 4.97

5.80 ± 4.33

104.52 ± 312.75

TG (mmol/l)

Normal

34.26 ± 38.59

200.69 ± 260.97

0.98 ± 1.13

0.41 ± 4.84

6.20 ± 6.98

176.88 ± 543.85

High

63.89 ± 40.88*

488.73 ± 413.19*

1.90 ± 1.21*

0.36 ± 4.78*

0.11 ± 7.27*

200.89 ± 168.69

HDL (mmol/l)

Normal

30.79 ± 36.05

198.31 ± 264.91

0.89 ± 1.07

0.42 ± 4.61

5.49 ± 6.35

162.85 ± 480.62

Low

43.71 ± 42.60*

238.33 ± 286.97

1.24 ± 1.23*

0.40 ± 5.24*

8.00 ± 0.08*

203.89 ± 615.34

Metabolic syndrome

Absent

35.33 ± 38.70

212.41 ± 267.37

1.02 ± 1.13

0.41 ± 4.8

6.38 ± 7.00

179.73 ± 540.38

Present

41.75 ± 50.73

229.53 ± 452.2

1.18 ± 1.49

0.42 ± 6.40

7.60 ± 8.87

115.66 ± 168.51

ALT (IU/l)

Normal

34.09 ± 38.13

202.63 ± 255.14

0.98 ± 1.11

0.41 ± 4.79

6.15 ± 6.85

170.11 ± 433.23

High

46.31 ± 47.42

324.83 ± 408.88*

1.37 ± 1.46

0.40 ± 5.75

8.17 ± 8.37

378.60 ± 979.31

Presence of number of abnormal metabolic abnormalities§

0

25.83 ± 22.53

137.60 ± 123.57

0.75 ± 0.68

0.42 ± 4.22

4.63 ± 3.96

150.98 ± 505.55

1

39.47 ± 47.61

237.02 ± 259.95

1.13 ± 1.41

0.41 ± 4.96

7.21 ± 8.42

189.48 ± 644.06

2

58.47 ± 51.17

404.74 ± 475.98

1.68 ± 1.42

0.38 ± 5.02

0.11 ± 0.10

249.12 ± 373.67

3

93.29 ± 45.84

514.99 ± 421.12

2.84 ± 1.29

0.33 ± 2.72

0.16 ± 8.25

217.72 ± 131.79

4

130.57

1391.93

3.68

0.32

0.24

417.24

%FM group

Normal

30.70 ± 37.73

160.79 ± 159.89

0.89 ± 1.10

0.42 ± 4.64

5.53 ± 0.07

160.55 ± 573.85

High

54.71 ± 38.40*

423.07 ± 469.82*

1.56 ± 1.14*

0.38 ± 4.56*

9.92 ± 6.98*

246.84 ± 318.68

  1. There were no children with elevated (>2SD) systolic BP
  2. * p < 0.05; when compared between normal and high value of each parameter assessed
  3. §One way ANOVA (Alpha 0.05) is used in the comparison of IR markers across different BMI categories, and across different numbers of metabolic derangements. Fasting insulin, HOMA-IR and FIGR differed from each BMI category. 2 h post glucose insulin and QUICKI the normal BMI category from other 2 BMI categories
  4. †BMI categorization is based on IOTF cutoff values
  5. ‡Based on British centile cutoff values
  6. ¥HOMA-B did not show significant differences across different BMI categories or number of metabolic derangements
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BMC Research Notes

ISSN: 1756-0500

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