Fig. 2

Effects of diet and exercise on markers of ribosome biogenesis. The effects of the intervention on c-Myc protein levels (a), UBF protein levels (b), RNA Pol I protein levels (c) and pre-45S rRNA transcript levels (d). e Representative images of Western blotting targets. All data are presented as mean ± SD (n = 10–16 rats per group), group mean values are presented within each bar, 95% confidence intervals are presented in parentheses within each bar, and bars with different superscript letters indicate between-treatment differences (p < 0.05). O-CON OLETF rats consuming a control diet during weeks 20–32 and were not treadmill-trained, O-WD/SED OLETF rats consuming a Western diet during weeks 20–32 and were not treadmill-trained, O-WD/EX OLETF rats consuming a Western diet during weeks 20–32 and were treadmill-trained 5 days/week