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Table 5 Comparison of the two techniques during IPP (20 min) plus hemofiltration (60 min) based on peripheral pharmacokinetic parameters

From: Surgical versus percutaneous isolated pelvic perfusion (IPP) for advanced melanoma: comparison in terms of melphalan pharmacokinetic pelvic bio-availability

Technique

Surgical

Percutaneous

MW

Median

IQR

Median

IQR

p value

Cmax (µg/ml)

2.3

(2 to 2.5)

2.0

(1.9 to 2)

0.084

AUC0 to 80 (µg/ml*min)

81.9

(78.4 to 84.7)

70.3

(64.8 to 81.7)

0.251

T1/2 (min)

13

(11.5 to 14)

16

(14 to 16.5)

0.076

Vd [mg/(µg/ml)]

6.5

(5.7 to 6.9)

8.6

(7.7 to 10.2)

0.075

Cl [mg/(µg/ml)/min]

12.3

(11.8 to 13.9)

15.8

(13.8 to 15.9)

0.175

  1. MW Mann–Whitney test, AUC 0 to 80 area under the plasma concentration curve (0 to 80 min), T 1/2 half-life of elimination phase, Vd volume of distribution, Cl total clearance (extracorporeal plus systemic)
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BMC Research Notes

ISSN: 1756-0500

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