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Table 5 Comparison of the two techniques during IPP (20 min) plus hemofiltration (60 min) based on peripheral pharmacokinetic parameters

From: Surgical versus percutaneous isolated pelvic perfusion (IPP) for advanced melanoma: comparison in terms of melphalan pharmacokinetic pelvic bio-availability

Technique Surgical Percutaneous MW
Median IQR Median IQR p value
Cmax (µg/ml) 2.3 (2 to 2.5) 2.0 (1.9 to 2) 0.084
AUC0 to 80 (µg/ml*min) 81.9 (78.4 to 84.7) 70.3 (64.8 to 81.7) 0.251
T1/2 (min) 13 (11.5 to 14) 16 (14 to 16.5) 0.076
Vd [mg/(µg/ml)] 6.5 (5.7 to 6.9) 8.6 (7.7 to 10.2) 0.075
Cl [mg/(µg/ml)/min] 12.3 (11.8 to 13.9) 15.8 (13.8 to 15.9) 0.175
  1. MW Mann–Whitney test, AUC 0 to 80 area under the plasma concentration curve (0 to 80 min), T 1/2 half-life of elimination phase, Vd volume of distribution, Cl total clearance (extracorporeal plus systemic)
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