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Table 3 IgG and IgG subclass levels in children during both periods of the malaria transmission seasons

From: Antibody responses to P. falciparum blood stage antigens and incidence of clinical malaria in children living in endemic area in Burkina Faso

Antigen Isotype N Low transmission season High transmission season p*
Geometric mean (95% CI) Geometric mean (95% CI)
MSP3 IgG 325 2.55 (2.12, 3.08) 7.29 (6.12, 8.67) <.0001
  IgG1 325 4.35 (3.85, 4.92) 9.41 (8.47, 10.44) <.0001
  IgG2 325 4.95 (4.48, 5.47) 4.96 (4.53, 5.42) 0.065
  IgG3 325 1.33 (1.08, 1.63) 2.89 (2.42, 3.45) <.0001
  IgG4 325 3.15 (2.88, 3.45) 2.95 (2.64, 3.29) <.0001
MSP2a IgG 325 14.82 (11.92, 18.43) 33.21 (27.79, 39.67) <.0001
  IgG1 325 3.60 (3.11, 4.16) 5.73 (4.92, 6.67) 0.0012
  IgG2 325 3.38 (3.08, 3.71) 3.95 (3.46, 4.51) <.0001
  IgG3 325 12.43 (10.22, 15.11) 15.04 (12.48, 18.13) 0.0147
  IgG4 325 2.52 (2.08, 3.05) 2.64 (2.21, 3.15) 0.0539
MSP2b IgG 325 24.50 (19.63, 30.57) 37.01 (31.38, 43.66) 0.3356
  IgG1 325 5.66 (4.89, 6.55) 13.15 (11.58, 14.93) <.0001
  IgG2 325 4.29 (3.94, 4.66) 3.62 (3.12, 4.21) 0.1138
  IgG3 325 11.90 (9.56, 14.81) 13.73 (11.19, 16.85) 0.4537
  IgG4 325 1.65 (1.31, 2.08) 1.99 (1.64, 2.42) 0.3316
GLURP-R0 IgG 325 3.65 (3.03, 4.41) 6.31 (5.08, 7.84) <.0001
  IgG1 325 3.76 (3.24, 4.35) 3.38 (2.87, 3.98) 0.2451
  IgG2 325 1.13 (1.01, 1.26) 4.45 (3.93, 5.04) <.0001
  IgG3 325 1.46 (1.24, 1.71) 0.97 (0.82, 1.14) <.0001
  IgG4 325 1.62 (1.42, 1.85) 0.34 (0.30, 0.38) <.0001
GLURP-R2 IgG 325 33.45 (27.73, 40.36) 31.60 (26.44, 37.77) 0.0372
  IgG1 325 17.59 (14.02, 22.06) 41.35 (34.08, 50.17) <.0001
  IgG2 325 7.42 (5.84, 9.43) 30.11 (26.56, 34.14) <.0001
  IgG3 325 16.77 (13.17, 21.36) 12.87 (10.02, 16.52) 0.0001
  IgG4 325 6.87 (6.01, 7.85) 5.07 (4.40, 5.85) <.0001
  1. *  p ≤ 0.05 was considered as statistically significant