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Table 3 IgG and IgG subclass levels in children during both periods of the malaria transmission seasons

From: Antibody responses to P. falciparum blood stage antigens and incidence of clinical malaria in children living in endemic area in Burkina Faso

Antigen

Isotype

N

Low transmission season

High transmission season

p*

Geometric mean

(95% CI)

Geometric mean

(95% CI)

MSP3

IgG

325

2.55

(2.12, 3.08)

7.29

(6.12, 8.67)

<.0001

 

IgG1

325

4.35

(3.85, 4.92)

9.41

(8.47, 10.44)

<.0001

 

IgG2

325

4.95

(4.48, 5.47)

4.96

(4.53, 5.42)

0.065

 

IgG3

325

1.33

(1.08, 1.63)

2.89

(2.42, 3.45)

<.0001

 

IgG4

325

3.15

(2.88, 3.45)

2.95

(2.64, 3.29)

<.0001

MSP2a

IgG

325

14.82

(11.92, 18.43)

33.21

(27.79, 39.67)

<.0001

 

IgG1

325

3.60

(3.11, 4.16)

5.73

(4.92, 6.67)

0.0012

 

IgG2

325

3.38

(3.08, 3.71)

3.95

(3.46, 4.51)

<.0001

 

IgG3

325

12.43

(10.22, 15.11)

15.04

(12.48, 18.13)

0.0147

 

IgG4

325

2.52

(2.08, 3.05)

2.64

(2.21, 3.15)

0.0539

MSP2b

IgG

325

24.50

(19.63, 30.57)

37.01

(31.38, 43.66)

0.3356

 

IgG1

325

5.66

(4.89, 6.55)

13.15

(11.58, 14.93)

<.0001

 

IgG2

325

4.29

(3.94, 4.66)

3.62

(3.12, 4.21)

0.1138

 

IgG3

325

11.90

(9.56, 14.81)

13.73

(11.19, 16.85)

0.4537

 

IgG4

325

1.65

(1.31, 2.08)

1.99

(1.64, 2.42)

0.3316

GLURP-R0

IgG

325

3.65

(3.03, 4.41)

6.31

(5.08, 7.84)

<.0001

 

IgG1

325

3.76

(3.24, 4.35)

3.38

(2.87, 3.98)

0.2451

 

IgG2

325

1.13

(1.01, 1.26)

4.45

(3.93, 5.04)

<.0001

 

IgG3

325

1.46

(1.24, 1.71)

0.97

(0.82, 1.14)

<.0001

 

IgG4

325

1.62

(1.42, 1.85)

0.34

(0.30, 0.38)

<.0001

GLURP-R2

IgG

325

33.45

(27.73, 40.36)

31.60

(26.44, 37.77)

0.0372

 

IgG1

325

17.59

(14.02, 22.06)

41.35

(34.08, 50.17)

<.0001

 

IgG2

325

7.42

(5.84, 9.43)

30.11

(26.56, 34.14)

<.0001

 

IgG3

325

16.77

(13.17, 21.36)

12.87

(10.02, 16.52)

0.0001

 

IgG4

325

6.87

(6.01, 7.85)

5.07

(4.40, 5.85)

<.0001

  1. *  p ≤ 0.05 was considered as statistically significant