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Table 2 Association of K2p gene expression and triple negative subtype

From: Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation

  Age/race adjusteda Mutually adjustedb Fully adjustedc
RR 95% CI p-valued RR 95% CI p-valuee RR 95% CI p-valuee
KCNK1 1.02 0.94 1.10 6.50E−01
KCNK2 0.88 0.63 1.22 4.28E−01
KCNK3 0.95 0.74 1.24 7.25E−01
KCNK4 1.02 0.94 1.10 6.66E−01
KCNK5 1.03 1.02 1.04 2.92E−09 2.51 1.88 3.36 4.26E−10 2.22 1.67 2.96 3.81E−08
KCNK6 0.24 0.17 0.33 1.38E−17 0.87 0.76 0.99 2.96E−02 0.88 0.77 1.01 7.68E−02
KCNK7 0.97 0.90 1.05 5.09E−01
KCNK9 1.02 1.01 1.03 1.43E−03 1.18 1.08 1.30 2.91E−04 1.16 1.06 1.28 2.39E−03
KCNK10 1.06 1.00 1.13 4.44E−02
KCNK12 1.03 1.02 1.04 8.93E−09 1.54 1.36 1.74 4.60E−12 1.54 1.35 1.76 1.74E−10
KCNK13 0.90 0.74 1.08 2.57E−01
KCNK15 0.0036 0.00 0.01 2.21E−19 0.28 0.20 0.38 4.44E−16 0.27 0.19 0.38 2.86E−14
KCNK16 0.0199 0.00 5.31 1.69E−01
KCNK17 1.03 0.91 1.16 6.32E−01
KCNK18 1.03 0.96 1.10 4.55E−01
  1. mRNA Expression z-Scores (RNA Seq V2 RSEM)
  2. Reference group for triple negative subtype is luminal A
  3. K2p 2-Pore domain potassium channel, ellipses not applicable
  4. aModels adjusted for race and age, and K2p gene expression is modeled as individual continuous covariates (n = 482)
  5. bModels adjusted for race, age and other selected K2p gene expression variables as continuous covariates, while main K2p gene of interest is modeled as categorical tertiles (n = 482); only significant K2p gene expression from univariate glm included
  6. cFully adjusted model adds stage as an ordinal variable and menopausal status as a binary variable to the mutually adjusted mode; only significant K2p gene expression from univariate glm included
  7. dFrom logistic regression models (glm), Bonferroni adjusted significance threshold = p < 0.0033 (significant values are in italics)
  8. eFrom glm models p-trend, Bonferroni adjusted significance threshold = p < 0.0033