Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation

Table 2 Association of K2p gene expression and triple negative subtype

mRNA Expression z-Scores (RNA Seq V2 RSEM)
Reference group for triple negative subtype is luminal A
K2p 2-Pore domain potassium channel, ellipses not applicable
^aModels adjusted for race and age, and K2p gene expression is modeled as individual continuous covariates (n = 482)
^bModels adjusted for race, age and other selected K2p gene expression variables as continuous covariates, while main K2p gene of interest is modeled as categorical tertiles (n = 482); only significant K2p gene expression from univariate glm included
^cFully adjusted model adds stage as an ordinal variable and menopausal status as a binary variable to the mutually adjusted mode; only significant K2p gene expression from univariate glm included
^dFrom logistic regression models (glm), Bonferroni adjusted significance threshold = p < 0.0033 (significant values are in italics)
^eFrom glm models p-trend, Bonferroni adjusted significance threshold = p < 0.0033

ISSN: 1756-0500