Fig. 3
a Lactate levels, b PaO2:FiO2 ratios, c AST levels and d creatine kinase concentrations throughout the experiment. Data presented as least-squares means with 95% confidence intervals. +p < 0.05 for LR vs 4 M BHB/10mM M; ▲p < 0.05 for LR vs 4 M BHB/20 mM M and 4 M BHB/10 mM M and 4 M BHB/0.43 mM M, 4 M BHB/0.43 mM M vs 4 M BHB/43 mM M and 4 M BHB/4.3 mM M. *p < 0.05 for LR vs 4 M BHB/20 mM M; # for 4 M BHB/10 mM M versus 4 M BHB/4.3 mM M and 4 M BHB/43 mM M; $ for 4 M BHB/10 mM M vs LR and 4 M BHB/43 mM M and 4 M BHB/20 mM M and 4 M BHB/4.3 mM M. AST aspartate aminotransferase, BHB d-β-hydroxybutyrate, CK total creatine kinase, FiO 2 inspired fraction of oxygen, FR full resuscitation, G group effect, G * T group * time interaction effect, LR lactated Ringer’s solution, M melatonin, PaO 2 partial arterial pressure of oxygen, R limited resuscitation, S 45 min end of shock period, T time effect