|
Variables
|
Simple Cox regression
|
Multiple Cox regression
|
|---|
|
b
|
Crude HR (95% CI)
|
p value
|
b
|
Adjusted HR (95% CI)
|
p value
|
|---|
|
Age (year)
|
0.02
|
1.02 (1.01, 1.04)
|
0.005
|
0.03
|
1.03 (1.01, 1.04)
|
0.001
|
|
Metastases
|
|
No
|
0.00
|
1.00
|
–
|
0.00
|
1.00
|
–
|
|
Yes
|
1.11
|
3.02 (1.29, 7.09)
|
0.011
|
0.92
|
2.52 (1.01, 6.28)
|
0.048
|
|
AJCC stage
|
|
I–II
|
0.00
|
1.00
|
–
|
0.00
|
1.00
|
–
|
|
III
|
0.45
|
1.81 (0.75, 4.38)
|
0.190
|
0.88
|
2.42 (0.98, 5.99)
|
0.056
|
|
IV
|
0.44
|
3.41 (1.44, 8.08)
|
0.005
|
1.40
|
4.05 (1.66, 9.88)
|
0.002
|
- A backward stepwise Cox proportional hazards regression model was applied. Two-way interaction and multicollinearity were assessed and not found. A log-minus-log plot, a hazard function plot and Schoenfeld residuals were applied to test the model assumptions. Martingale residuals, Cox-Snell residuals, deviance residuals and influence analysis were used to assess the fit of the model and to identify influential cases
-
b regression coefficient
