Variables

Simple Cox regression

Multiple Cox regression


b

Crude HR (95% CI)

p value

b

Adjusted HR (95% CI)

p value


Age (year)

0.02

1.02 (1.01, 1.04)

0.005

0.03

1.03 (1.01, 1.04)

0.001

Metastases

No

0.00

1.00

–

0.00

1.00

–

Yes

1.11

3.02 (1.29, 7.09)

0.011

0.92

2.52 (1.01, 6.28)

0.048

AJCC stage

I–II

0.00

1.00

–

0.00

1.00

–

III

0.45

1.81 (0.75, 4.38)

0.190

0.88

2.42 (0.98, 5.99)

0.056

IV

0.44

3.41 (1.44, 8.08)

0.005

1.40

4.05 (1.66, 9.88)

0.002

 A backward stepwise Cox proportional hazards regression model was applied. Twoway interaction and multicollinearity were assessed and not found. A logminuslog plot, a hazard function plot and Schoenfeld residuals were applied to test the model assumptions. Martingale residuals, CoxSnell residuals, deviance residuals and influence analysis were used to assess the fit of the model and to identify influential cases

b regression coefficient