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Table 6 The final simple and multivariate Cox proportional hazard regression model of prognostic factors associated with the survival of NPC patients in Hospital USM (n = 134)

From: Prognostic factors of nasopharyngeal carcinoma patients in a tertiary referral hospital: a retrospective cohort study

Variables Simple Cox regression Multiple Cox regression
b Crude HR (95% CI) p value b Adjusted HR (95% CI) p value
Age (year) 0.02 1.02 (1.01, 1.04) 0.005 0.03 1.03 (1.01, 1.04) 0.001
Metastases
 No 0.00 1.00 0.00 1.00
 Yes 1.11 3.02 (1.29, 7.09) 0.011 0.92 2.52 (1.01, 6.28) 0.048
AJCC stage
 I–II 0.00 1.00 0.00 1.00
 III 0.45 1.81 (0.75, 4.38) 0.190 0.88 2.42 (0.98, 5.99) 0.056
 IV 0.44 3.41 (1.44, 8.08) 0.005 1.40 4.05 (1.66, 9.88) 0.002
  1. A backward stepwise Cox proportional hazards regression model was applied. Two-way interaction and multicollinearity were assessed and not found. A log-minus-log plot, a hazard function plot and Schoenfeld residuals were applied to test the model assumptions. Martingale residuals, Cox-Snell residuals, deviance residuals and influence analysis were used to assess the fit of the model and to identify influential cases
  2. b regression coefficient