Fig. 1

Rac–Rock–Rho pathway regulation of Cell–Cell junctions and actin cytoskeleton dynamics affect intestinal epithelial permeability. a Schematic of epithelial cell–cell junctions. b Detailed view of protein–protein interactions between the tight junction and actin cytoskeleton. c Degradation of intestinal epithelial barrier function allows solutes and macromolecules across the intestinal barrier. d Pathway structure of Rac–Rock–Rho activity affecting the actin cytoskeleton and cell–cell junctions